Setsunan University

 

 

 

 

 

 

 

 

vision

研究業績

Professor

Name Takeshi Nabe, Ph.D. t-nabe*pharm.setsunan.ac.jp (* is @)

Publications ORCID ID PubMed Listing

Biographical sketch

Education
1984-1988 B.S., Kyoto Pharmaceutical University, Kyoto, Japan (Licensed as Pharmacist)
1988-1990 M.S., Graduate School, Kyoto Pharmaceutical University
1998 Awarded Ph.D. from Kyoto Pharmaceutical University

Position and Employment
1990-1998 Assistant Professor, Dept. of Pharmacology, Kyoto Pharmaceutical University
1999-2014 Associate Professor, Dept. of Pharmacology, Kyoto Pharmaceutical University

2001-2002 Post-doctoral fellow, Dept. of Microbiology, University of Alabama at Birmingham, AL, USA (PI: Prof. David D. Chaplin)
2014-Present Professor, Lab. of Immunopharmacology, Setsunan University, Osaka, Japan

Professional memberships
The Japanese Pharmacological Society (Delegate); Japanese Society of Allergology; The Pharmaceutical Society of Japan (Delegate);
Japanese Society for Immunology; Japanese Society of Inflammation and Regeneration; Japanese Society for Ocular Pharmacology (Director)

Research/Clinical Interest

Title 1: Interplay between innate and adaptive immunity in asthmatic inflammation, and its pharmacological modulation

We aim to define the ways innate immune stimuli modulate allergic inflammatory responses that are manifested in tissues through the action of the adaptive immune response. We have a special interest in IL-33 generated from airway epithelial cells and hematopoietic cells affects Th2-driven airway inflammation leading to establishment of airway remodeling. Suppression of IL-33’s production and action could lead suppression of asthma. We are analyzing mechanisms underlying the asthma pathogenesis by using murine model of allergic airway inflammation, and testing pharmacological effects of various compounds on IL-33’s production and action. The IL-33 axis may be a valuable target for future development of novel anti-asthmatic therapeutics. Recently, molecular mechanisms underlying steroid-resistant asthma are also being analyzed using the murine model.

Title 2: Roles of induced regulatory T cells (Tr1) cells in immunotherapy for atopic diseases

Mechanisms of effectiveness of subcutaneous and sublingual immunotherapy have not been clear. Using murine models of atopic diseases and peripheral blood mononuclear cells of pollenosis patients, we are analyzing the mechanisms by focusing on induction of Tr1 cells. In addition, we are trying to develop efficient methods for induction of Tr1 cells in vivo by drugs or probiotics. Furthermore, we aim to develop therapeutic methods for atopic diseases using in vitro differenticated Tr1 cells, which respond specifically to a corresponding antigen protein.

Title 3: Pharmacological analyses of mechanisms of lung fibrosis

There have not been good theraputic drugs for drug-induced and allergic lung fibrosis. Using murine models of lung fibrosis, we have pharmacologically analyzed mechanisms of lung fibrosis.

Associate professor

Name Kazuyuki Kitatani, Ph.D. kazuyuki.kitatani*pharm.setsunan.ac.jp (* is @)

Publications ORCID ID

Biographical sketch

Education
1993-1997 B.S., Kyoto Pharmaceutical University, Kyoto, Japan (Licensed as Pharmacist)
1997-1999 M.S., Graduate School, Kyoto Pharmaceutical University
1999-2002 Ph.D., Graduate School, Kyoto Pharmaceutical University

Position and Employment
2002-2007 Post-doctoral fellow, Yusuf A. Hannun Lab, Department of Biochemistry and Molecular Biology, Medical University of South
Carolina, Charleston, SC, U.S.A.

2007-2008 Instructor, Department of Biochemistry and Molecular Biology, Medical University of South Carolina
2008-2012 Assistant Professor, Department of Clinical Laboratory, Tottori University Hospital, Yonago, Japan
2012-2017 Assistant Professor, Tohoku Medical Megabank Organization/Department of Obstetrics and Gynecology, Tohoku University,
Sendai, Japan
2017-2018 Senior Assistant Professor, Tohoku Medical Megabank Organization/Department of Obstetrics and Gynecology, Tohoku University
2018-Present Associate Professor, Lab. of Immunopharmacology, Setsunan University, Osaka, Japan

Professional memberships
1997– The Japanese Biochemical Society
1997– The Pharmaceutical Society of Japan;
2007– The American Society for Biochemistry and Molecular Biology (ASBMB)
2009– The Japanese Conference on the Biochemistry of Lipids (JCBL)
2012– The Japan Society of Obstetrics and Gynecology (JSOG)
2014–2016 Lead guest editor, Mediators of Inflammation
2016-present Editorial board, Journal of Gynecology & Reproductive Medicine

Research/Clinical Interest

Title 1: Sphingolipid function

Our laboratory is interested in delineating the function of bioactive sphingolipids including ceramide, sphingosine-1-phosphate, and sphingosine. Especially we study on defining the roles of sphingolipids in cell motility and programmed necrosis (necroptosis).

Title 2: Ceramide-centered therapy

We study molecular pharmacology of ceramide nanoliposomes and ceramide-centered therapeutics for cancer and inflammatory diseases.

Title 3: Drug discovery for cancer

Our laboratory has studied chemo-resistance and metastasis in cancer. Cancer develops with chemo-resistance and/or metastasis and defining the regulatory mechanisms gives insight into drug discovery. We focus on addressing the molecular mechanisms and finding the molecular target for cancer treatment. In addition, we are proposing necroptosis as a target for cancer therapy and focus on discovering necroptosis-based antitumor reagents.