Publications
2023
In vitro demonstration of antedrug mechanism of a pharmacokinetic booster to improve CYP3A4 substrates by CYP3A4-mediated metabolism inhibition
Kataoka M, Takenaka S, Fujii S, Masada T, Minami K, Takagi T, Omote M, Kawai K, Yamashita S
Drug Metab Pharmacokinet. in press (2024). [PubMed] [Science Direct]
Near-infrared imaging of in vivo performance of orally administered solid
forms to rats: Feasibility study with indocyanine green
Kataoka M, Itaka Y, Masada T, Minami K, Higashino H, Yamashita S
Int J Pharm. 649:123677 (2024). [PubMed] [Science Direct]
Development of an In Vitro Methodology to Assess the Bioequivalence of
Orally Disintegrating Tablets Taken Without Water
Takagi T, Masada T, Minami K, Kataoka M, Yamashita S.
Pharmaceutics 2023, 15, 2192. [PubMed] [MDPI]
Control of dissolution and supersaturation/precipitation of poorly water-soluble
drugs from cocrystals based on solubility products: A case study with a
ketoconazole cocrystal
Kataoka M, Yonehara A, Minami K, Takagi T, Yamashita S.
Mol Pharm. 2023, 20(8):4100-4107. [PubMed] [ACS Publications]
The Effects of Degree and Duration of Supersaturation on In Vivo Absorption
Profiles for Highly Permeable Drugs, Dipyridamole and Ketoconazole
Higashino H, Minami K, Takagi T, Kataoka M, Yamashita S
Eur J Pharm Biopharm. 189:48-55 (2023). [PubMed] [Science Direct]
Contribution analysis of metabolic tissues on systemic exposure of an active
metabolite after oral administration of verapamil using a stable isotope-labeled
compound
Kataoka M, Ohshiro S, Minami K, Hasegawa T, Higashino H, Takagi T, Togashi K, Mutaguchi K, Yamashita S
Drug Metab Pharmacokinet. 51:100514 (2023). [PubMed] [Science Direct]
Development of New Sublingual Formulation for Transmucosal Delivery of Peptides
Minami K, Kataoka M, Takagi T, Nii T, Tabata Y, Yamashita S
Yakugaku Zasshi. 143(4):345-348 (2023). [PubMed] [J-Stage]
2022
Effects of ingested water volume on oral absorption of fenofibrate, a BCS class II drug, from micronized and amorphous solid dispersion formulations in rats
Kataoka M, Ikkou S, Kato Y, Minami K, Higashino H, Takagi T, Yamashita S
Biol Pharm Bull. 45:1452-1457 (2022). [PubMed] [J-Stage]
Discovery of benzyloxyphenyl- and phenethylphenyl-imidazole derivatives
as a new class of ante?drug type boosters
Kawai K, Okada J, Nakae M, Tsujimura T, Karuo Y, Tarui A, Sato K, Yamashita S, Kataoka M, Omote M
Bioorg Med Chem Lett. 72 (2022) 128868. [PubMed] [Science Direct]
Mechanistic analysis for positive and negative food effects on oral absorption
of poorly soluble drugs from cyclodextrin containing formulations: Study
with a mini-scale in vitro system
Aihara R, Minami K, Messerschmid R, Wada K, Takagi T, Yamashita S.
J Drug Deliv Sci Technol. 60 (2022) 103440. [Science Direct]
Liposomal Formulation for Oral Delivery of Cyclosporine A: Usefulness as a Semisolid-Dispersion System
Minami K, Kataoka M, Takagi T, Asai T, Oku N, Yamashita S
Pharm Res 39:977-987 (2022). [PubMed] [SpringerLink]
2021
Importance of Gastric Secretion and the Rapid Gastric Emptying of Ingested Water along the Lesser Curvature (“Magenstra?e”) in Predicting the In Vivo Performance of Liquid Oral Dosage Forms in the Fed State Using a Modeling and Simulation
Kiyota T, Kambayashi A, Takagi T, Yamashita S
Mol Pharm. 19:2 642-653 (2022). [PubMed] [ACS Publications]
Interspecies differences in gastrointestinal physiology affecting the in
vivo performance of oral pharmaceutical solid dosage forms
Kambayashi A, Murano M, Imai S, Miyata K, Sugita K, Fujii Y, Kinoshita M, Nomura A, Kimoto T, Miyazaki Y, Sakakibara H, Kakuda S, Tsujimoto T, Fujita Y, Kano M, Nakamura H, Akaogi S, Honda M, Anraku M, Kamada N, Ohta K, Uchida M, Kataoka M, Kikuchi H, Yamashita S, Kondo H
J Drug Deliv Sci Technol. (2022) 102923 [Science Direct]
In vitro-in vivo correlation in cocrystal dissolution: Consideration of
drug release profiles based on coformer dissolution and absorption behavior
Kataoka M, Minami K, Takagi T, Amidon GE, Yamashita S
Mol Pharmaceutics 18(11) 4122-4130 (2021). [PubMed] [ACS Publications]
Maximizing the Oral Bioavailability of Poorly Water-soluble Drug Using
Novel Oil-like Material in Lipid-based Formulations
Abbasi S, Higashino H, Sato Y, Minami K, Kataoka M, Yamashita S, Harashima H
Mol Pharm. 18:3281-3289 (2021). [PubMed] [ACS Publications]
Bioequivalence of Oral Drug Products in the Healthy and Special Populations:
Assessment and Prediction Using a Newly Developed In Vitro System “BE
Checker”
Masada T, Takagi T, Minami K, Kataoka M, Izutsu K, Matsui K, Yamashita S
Pharmaceutics 13(8), 1136 (2021). [PubMed] [MDPI]
New biphasic system in side-by-side chambers for testing drug dissolution and permeation in vitro (BiDP system)
Masada T, Takagi T, Minami K, Kataoka M, Takeyama S, Fujii Y, Takahashi M, Yamashita S
J Drug Deliv Sci Technol. 65 (2021) 102747 [Science Direct]
2020
In vitro -in vivo correlation in the effect of cyclodextrin on oral absorption of poorly soluble drugs
Aihara R, Messerschmid R, Mizoguchi M, Wada K, Minami K, Higashino H, Takagi T, Kataoka M, Yamashita S
Int J Pharm. 600 120494 (2021). [PubMed] [Science Direct]
In Vitro Sensitivity Analysis of the Gastrointestinal Dissolution Profile
of Weakly Basic Drugs in the Stomach-to-Intestine Fluid Changing System:
Explanation for Variable Plasma Exposure after Oral Administration
Takagi T, Masada T, Minami K, Kataoka M, Izutsu K, Matsui K, Yamashita S
Mol Pharm.18:1711-1719 (2021). [PubMed] [ACS Publications]
In vivo screening of oral formulations using rats: Effects of ingested
water volume on oral absorption of BCS class I and III drugs from immediate-release
formulations
Kataoka M, Morimoto S, Minami K, Higashino H, Nakano M, Tomita Y, Nagato T, Yamashita S
J Drug Deliv Sci Technol. 60 102100 (2020). [Science Direct]
Species differences in the drug-drug interaction between atorvastatin and cyclosporine: In vivo study using a stable isotope-IV method in rats and dogs
Minami K, Higashino H, Kataoka M, Yamashita S
Eur J Pharm Sci. 152:105409 (2020). [PubMed]
An enteric polymer mitigates the effects of gastric pH on oral absorption of poorly soluble weak acid drugs from supersaturable formulations: A case study with dantrolene
Kataoka M, Nakanishi R, Umesaki M, Kobayashi M, Minami K, Higashino H, Yamaguchi S, Yamashita S
Eur J Pharm Biopharm. 155:29-36 (2020). [PubMed]
Extent and rate of oral drug absorption in minipigs: Comparison with mice, rats and humans
Yoshimatsu H, Ishii K, Yamashita S
J Drug Deliv Sci Technol. 58 (2020) 101743. {Science Direct]
2019
Control of oral absorption of nutritional supplement using lipid-based formulations (LBFs): Application to the poorly water-soluble ingredient
Higashino H, Minami K, Kataoka M, Tomimori N, Rogi T, Shibata H, Yamashita S
J Drug Deliv Sci Technol. 57:101675 (2020). [Science Direct]
In Vivo Fluid Volume in Rat Gastrointestinal Tract: Kinetic Analysis on the Luminal Concentration of Nonabsorbable FITC-Dextran After Oral Administration
Tanaka Y, Higashino H, Kataoka M, Yamashita S
J Pharm Sci. 109(6):1863-1866 (2020). [PubMed]
Impact of dietary intake of medium-chain triacylglycerides on the intestinal absorption of poorly permeable compounds
Kataoka M, Ohi Y, Sakanoue K, Minami K, Higashino H, Yamashita S
Mol Pharm. 17(1):212-218 (2020). [PubMed]
Biopredictive in vitro testing methods to assess intestinal drug absorption from supersaturating dosage forms
Hens B, Kataoka M, Ueda K, Gao P, Tsume Y, Augustijns P, Kawakami K, Yamashita S
J Drug Deliv Sci Technol. 56B 101275 (2020). [Science Direct]
Challenge for oral delivery of middle-molecular drugs: Use of osmolarity-sensitive liposome as a drug carrier in the GI tract?
Minami K, Takazawa A, Taniguchi Y, Higashino H, Kataoka M, Asai T, Oku N, Yamashita S
J Drug Deliv Sci Technol. 56B 101041 (2020) . [Science Direct]
2018
Analysis of the complicated nonlinear pharmacokinetics of orally administered
telmisartan in rats using a stable isotope-IV method.
Minami K, Higashino H, Kataoka M, Togashi K, Mutaguchi K, Yamashita S.
J Pharm Sci. 108(8):2774-2780 (2019). [PubMed]
In vitro assessment of supersaturation/precipitation and biological membrane
permeation of poorly water-soluble drugs: a case study with albendazole
and ketoconazole.
Kataoka M, Takeyama S, Minami K, Higashino H, Kakimi K, Fujii Y, Takahashi M, Yamashita S.
J Pharm Sci. 108(8):2580-2587 (2019). [PubMed]
Evaluation of Using Dogs to Predict Fraction of Oral Dose Absorbed in Humans for Poorly Water-Soluble Drugs.
Matsumura N, Yamaura Y, Katagi J, Ono S, Kim S, Yamashita S, Sugano K.
J Pharm Sci. 107(9):2489-2496 (2018). [PubMed]
Application of an in vitro dissolution/permeation system to early screening of oral formulations of poorly soluble, weakly basic drugs containing an acidic pH-modifier.
Mizoguchi M, Kataoka M, Yokoyama K, Aihara R, Wada K, Yamashita S.
J Pharm Sci. 107(9) 2404-2410 (2018). [PubMed]
2017
Prediction of human percutaneous absorption from in vitro and in vivo animal experiments.
Yoshimatsu H, Ishii K, Konno Y, Satsukawa M, Yamashita S.
Int J Pharm. 534(1-2):348-355 (2017). [PubMed]
Dodecylmaltoside Modulates Bicellular Tight Junction Contacts To Promote
Enhanced Permeability.
Gradauer K, Iida M, Watari A, Kataoka M, Yamashita S, Kondoh M, Buckley ST.
Mol Pharm. 14(12) 4734-4740 (2017). [PubMed]
Comparison of pharmacokinetics of newly discovered aromatase inhibitors
by a cassette microdosing approach in healthy Japanese subjects.
Kusuhara H, Takashima T, Fujii H, Takashima T, Tanaka M, Ishii A, Tazawa S, Takahashi K, Takahashi K, Tokai H, Yano T, Kataoka M, Inano A, Yoshida S, Hosoya T, Sugiyama Y, Yamashita S, Hojo T, Watanabe Y.
Drug Metab Pharmacokinet. 32(6):293-300 (2017). [PubMed]
Feasibility of Formulation for Microdose Clinical Study
Togashi K, Mutaguchi K, Komuro S, Kataoka M, Yamazaki H, Yamashita S, Sugiyama Y:
薬剤学. 77 (3) 177-185 (2017). [J-stage]
Quantitative Analysis of the Transporter-Mediated Drug-Drug Interaction Between Atorvastatin and Rifampicin Using a Stable Isotope-IV Method.
Yamashita S, Hasegawa T, Tachihara M, Minami K, Higashino H, Togashi K, Mutaguchi K, Kataoka M
J Pharm Sci. 106(9) 2671-2677 (2017). [PubMed]
2016
Design of supersaturable formulation of telmisartan with pH modifier: in
vitro study on dissolution and precipitation
Yamashita S, Fukunishi A, Higashino H, Kataoka M, Wada K
Journal of Pharmaceutical Investigation 47(2) 163-171 (2017). {Springer Link}
Increase in the systemic exposure of primary metabolites of Midazolam in
rat arising from CYP inhibition or hepatic dysfunction
Hasegawa T, Nakanishi S, Minami K, Higashino H, Kataoka M, Shitara Y, Yamashita S
Drug Metab Pharmacokinet. 32(1) 69-76 (2017). [PubMed].
Quantitative analysis of pharmacokinetic profiles of verapamil and drug-drug
interactions induced by a CYP inhibitor using a stable isotope-labeled
compound
Kataoka M, Kojima C, Ueda K, Minami K, Higashino H, Sakuma S, Togashi K, Mutaguchi K, Yamashita S
Drug Metab Pharmacokinet. 31(6) 405-410 (2016) [PubMed].
長期実務実習終了学生に対するアドバンスト臨床能力試験の実施による実習成果の実証
小森 浩二, 片岡 誠, 倉本 展行, 辻 琢己, 中谷 尊史, 安原 智久, 三田村 しのぶ, 塙 由美子, 荻田 喜代一
YAKUGAKU ZASSHI. 136(9) 1275-1284 (2016). [PubMed]
Systematic approach to optimize a pretreatment method for ultrasensitive
LC/MS/MS analysis of multiple target compounds in biological samples
Togashi K, Mutaguchi K, Nagae Y, Komuro S, Kataoka M, Yamashita S
.J Sep Sci. 39(16) 3212-3220 (2016). [PubMed]
Characterizing the Dissolution Profiles of Supersaturable Salts, Cocrystals,
and Solvates to Enhance In Vivo Oral Absorption.
Hisada N, Takano R, Takata N, Shiraki K, Ueto T, Tanida S, Kataoka M, Yamashita S
Eur J Pharm Biopharm. 103(1):192-9 (2016). [PubMed]
2015
Advantage of the Dissolution/Permeation system for estimating oral absorption
of drug candidates in the drug discovery stage.
Miyaji Y, Fujii Y, Takeyama S, Kawai Y, Kataoka M, Takahashi M, Yamashita S.
Mol Pharm. 2016 13(5) 1564-1572. [PubMed]
Effects of gastric pH on oral drug absorption: In vitro assessment using a dissolution/permeation system reflecting the gastric dissolution process
Kataoka M, Fukahori M, Ikemura A, Kubota A, Higashino H, Sakuma S, Yamashita S
Eur J Pharm Biopharm 101(1) 103-11 (2016). [PubMed]
Evaluation of dose-dependent oral absorption of a newly developed drug
candidate: in vitro-in vivo correlation
Yano K, Kataoka M, Ono S, Hiramatsu M, Matsumoto I, Kim SI, Higashino H, Sakuma S, Yamashita S
JDDST 31:160-166 (2016). [Science Direct]
Analysis of Intra- and Intersubject Variability in Oral Drug Absorption in Human Bioequivalence Studies of 113 Generic Products.
Sugihara M, Takeuchi S, Sugita M, Higaki K, Kataoka M, Yamashita S.
Mol Pharm. 12(12) 4405-4413 (2015). [PubMed]
An assessment of the oral bioavailability of three Ca-channel blockers using a cassette-microdose study: A new strategy for streamlining oral drug development
Yamashita S, Kataoka M, Suzaki Y, Imai H, Morimoto T, Ohashi K, Inano A, Togashi K, Mutaguchi K, Sugiyama Y
J Pharm Sci 104(9) 3154-3161 (2015). [PubMed].
Interaction with Mixed Micelles in the Intestine Attenuates the Permeation Enhancing Potential of Alkyl-Maltosides
Gradauer K, Nishiumi A, Unrinin K, Higashino H, Kataoka M, Pedersen BL, Buckley ST, Yamashita S
Mol Pharm. 12(7) 2245-2253 (2015). [PubMed]
Impact of Luminal Fluid Volume on the Drug Absorption after Oral Administration: Analysis Based on In vivo Drug Concentration-Time Profile in the Gastrointestinal Tract
Tanaka Y, Goto T, Kataoka M, Sakuma S, Yamashita S
J Pharm Sci 104(9) 3120-3127 (2015). [PubMed]
2014
Quantitative assessment of intestinal first-pass metabolism of oral drugs using portal-vein cannulated rats.
Matsuda Y, Konno Y, Hashimoto T, Nagai M, Taguchi T, Satsukawa M, Yamashita S.
Pharm Res. 32(2):604-616 (2015). [PubMed]
Cross-reactivity of immunoglobulin A secreted on the nasal mucosa in mice nasally inoculated with inactivated H1N1 influenza A viruses in the presence of D-octaarginine-linked polymers
Sakuma S, Morimoto N, Nishida K, Murakami T, Egawa T, Endo R, Kataoka M, Yamashita S, Miyata K, Mohri K, Ochiai K, Hiwatari K, Koike S, Tobita E, Uto T, Baba
M
Eur J Pharm Biopharm 92(1) 56-64 (2015). [PubMed]
A new in vitro system for evaluation of passive intestinal drug absorption:
establishment of a double artificial membrane permeation assay
Kataoka M, Tsuneishi S, Maeda Y, Masaoka Y, Sakuma S, Yamashita S
Eur J Pharm Biopharm. 88(3):840-6 (2014). [PubMed]
Effect of Excipients on the Particle Size of Precipitated Pioglitazone
in the Gastrointestinal Tract : Impact on Bioequivalence
Sugita M, Kataoka M, Sugihara M, Takeuchi S, Yamashita S
AAPS Journal 16(5):1119-27 (2014). [PubMed]
Inhibition mechanism of hydroxypropyl methylcellulose acetate succinate
on drug crystallization in gastrointestinal fluid and drug permeability
from a supersaturated solution
Ueda K, Higashi K, Kataoka M, Yamashita S, Yamamoto K, Moribe K
Eur J Pharm Sci. 62:293-300 (2014). [PubMed]
Specificity of lectin-immobilized fluorescent nanospheres for colorectal
tumors in a mouse model which more resembles the clinical disease
Kitamura T, Sakuma S, Shimosato M, Higashino H, Masaoka Y, Kataoka M, Yamashita S, Hiwatari K, Kumagai H, Morimoto N, Koike S, Tobita E, Hoffman RM, Gore JC, Pham W
Contrast Media and Molecular Imaging (2014) in press. [PubMed]
2013
In vitro-in vivo correlation in the effect of supersaturation on intestinal absorption of BCS class 2 drugs
HigashinoH, Hasegawa T, Yamamoto M, Matsui R, Masaoka Y, Kataoka M, Sakuma S, Yamashita S
Mol Pharm. 11(3):746-54 (2014). [PubMed]
Cyclodextrins improve oral absorption of a novel factor Xa inhibitor by
interfering with interaction between the drug and bile acids in rats
Fujii Y, Takahashi M, Ishiguro T, Sakuma S, Uekama K, Irie T
J Pharm Pharmacol. 65(11):1598-1606 (2013).. [PubMed]
Assessment of absorption potential of poorly water-soluble drugs by using
the dissolution/permeation system
Kataoka M, Yano K, Hamatsu Y, Masaoka Y, Sakuma S, Yamashita S.
Eur J Pharm Biopharm. 85(3B):1317-24 (2013). [PubMed]
Dynamic Analysis of Fluid Distribution in the Gastrointestinal Tract in
Rats: PET Imaging after Oral Administration of Non-absorbable Marker, [18F]Deoxyfluoropoly(ethylene
glycol)
Takashima T, Shingaki T, Katayama Y, Hayashinaka E, Wada Y, Kataoka M, Ozaki D, Doi H, Suzuki M, Ishida S, Hatanaka K,; Sugiyama Y, Akai S, Oku N, Yamashita S, Watanabe Y.
Mol Pharm. 10(6):2261-9 (2013). [PubMed]
Preparation of fenofibrate solid dispersion using electrospray deposition
and improvement in oral absorption by instantaneous post-heating of the
formulation.
Kawakami K, Zhang S, Chauhan RS, Ishizuka N, Yamamoto M, Masaoka Y, Kataoka M, Yamashita S, Sakuma S.
Int J Pharm. 450(1-2):123-8 (2013). [PubMed]
オリゴアルギニン固定化高分子を用いた低膜透過性分子の細胞膜透過促進
佐久間信至，日渡謙一郎
Drug Delivery System 28(2):109-118 (2013). [PubMed]
Establishment of MDCKII cell monolayer with metabolic activity by CYP3A4
transduced with recombinant adenovirus
Kataoka M, Terashima Y, Mizuno K, Masaoka Y, Sakuma S, Yokoi T, Yamashita S.
Drug Metab Pharmacokinet 27(2):125-31 (2013). [PubMed]
Measurement of drug concentration in the stomach after intragastric administration
of drug solution to healthy volunteers: Analysis of intragastric fluid
dynamics and drug absorption
Yamashita S, Kataoka M, Higashino H, Sakuma S, Sakamoto T, Uchimaru H, Tsukikawa H, Shiramoto M, Uchiyama H, Tachiki H, Irie S
Pharm Res. 30(4):951-8 (2013). [PubMed]
2012
Multifunctional Nanobeacon for Imaging Thomsen-Friedenreich Antigen-Associated Colorectal Cancer
Kumagai H, Pham W, Kataoka M, Hiwatari K, McBride J, Wilson K, Tachikawa H, Kimura R, Nakamura K, Liu E, Gore J, Sakuma S.
Int J Cancer. 132(9):2107-17 (2013). [PubMed]
Cell-penetrating peptide-linked polymers as carriers for mucosal vaccine
delivery
Sakuma S, Suita M, Inoue S, Marui Y, Nishida K, Masaoka Y, Kataoka M, Yamashita S, Nakajima N, Shinkai N, Yamauchi H, Hiwatari K, Tachikawa H, Kimura R, Uto, T, Baba M.
Mol Pharm. 9(10):2933-41 (2012). [PubMed]
Integrating drug permeability with dissolution profile to develop IVIVC
Takano R, Kataoka M, Yamashita S
Biopharm Drug Dispos. 33(7):354-65 (2012). [PubMed]
Dynamic analysis of GI absorption and hepatic distribution processes of telmisartan in rats using positron emission tomography
Kataoka M, Takashima T, Shingaki T, Hashidzume Y, Katayama Y, Wada Y, Oh H, Masaoka Y, Sakuma S. Sugiyama Y, Yamashita S, Watanabe Y
Pharm Res. 29(9):2419-31 (2012). [PubMed]
Dynamic analysis of pharmacokinetics of orally administered drugs using positron emission tomography
Kataoka M
Yakugaku Zasshi. 132(8):911-917 (2012). [PubMed]
Application of dissolution/permeation system for evaluation of formulation effect on oral absorption of poorly water-soluble drugs in drug development.
Kataoka M, Sugano K, Mathews C da C, Wong Jing Wen C, Jones K, Masaoka Y, Sakuma S, Yamashita S.
Pharm Res. 29(6):1485-94 (2012). [PubMed]
Involvement of functional groups on the surface of carboxyl group-terminated polyamidoamine dendrimers bearing arbutin in inhibition of Na+/glucose cotransporter 1 (SGLT1)-mediated D-glucose uptake
Sakuma S, Kanamitsu S, Teraoka Y, Masaoka Y, Kataoka M, Yamashita S, Shirasaka Y, Tamai I,Muraoka M, Nakatsuji Y, Kida T, Akashi M.
Mol Pharm. 9(4):922-9 (2012). [PubMed]
Imaging of Gastrointestinal Absorption and Biodistribution of Orally Administered Probe of Positron Emission Tomography in Human
Shingaki T, Takashima T, Wada Y, Tanaka M, Kataoka M, Ishii A, Shigihara Y, Sugiyama Y, Yamashita S, Watanabe Y
Clin Pharmacol Ther. 91(4):653-9 (2012). [PubMed]
Performance of cell-penetrating peptide-linked polymers physically mixed with poorly membrane-permeable molecules on cell membranes
Sakuma S, Suita M, Yamamoto T, Masaoka Y, Kataoka M, Yamashita S, Nakajima N, Shinkai N, Yamauchi H, Hiwatari K, Hashizume A, Tachikawa H, Kimura R, Ishimaru Y, Kasai A, Maeda S
Eur J Pharm Biopharm. 81(1):64-73 (2012). [PubMed]
2011
Impact of NEDO Project on Microdosing Clinical Studies: Toward the eIND Study in Japan.
Yamashita S.
Drug Metab Pharmacokinet. 26(6):549-50 (2011). [PubMed]
Improvement of low bioavailability of a novel factor Xa inhibitor through formulation of cationic additives in its oral dosage form.
Fujii Y, Kanamaru T, Kikuchi H, Nakagami H, Yamashita S, Akashi M, Sakuma S.
Int J Pharm. 421(2): 244-51 (2011). [PubMed]
Estimation of P-glycoprotein-mediated efflux in oral absorption of P-gp
substrate drugs from simultaneous analysis of drug dissolution and permeation
Kataoka M, Yokoyama T, Masaoka Y, Sakuma S, Yamashita S.
Eur J Pharm Sci. 44(4):544-51 (2011). [PubMed]
Lectin-Immobilized Fluorescent Nanospheres for Targeting to Colorectal Cancer from a Physicochemical Perspective.
Sakuma S, Yamashita S, Hiwatari KI, Hoffman RM, Pham W.
Curr Drug Discov Technol. 8(4):367-78 (2011). [PubMed]
Essence of affinity and specificity of peanut agglutinin-immobilized fluorescent nanospheres with surface poly(N-vinylacetamide) chains for colorectal cancer.
Sakuma S, Higashino H, Oshitani H, Masaoka Y, Kataoka M, Yamashita S, Hiwatari K, Tachikawa H, Kimura R, Nakamura K, Kumagai H, Gore JC, Pham W.
Eur J Pharm Biopharm. 79(3): 537-43 (2011). [PubMed]
A perspective for biowaivers of human bioequivalence studies on the basis of the combination of the ratio of AUC to the dose and the biopharmaceutics classification system.
Sakuma S, Tachiki H, Uchiyama H, Fukui Y, Takeuchi N, Kumamoto K, Satoh T, Yamamoto Y, Ishii E, Sakai Y, Takeuchi S, Sugita M, Yamashita S.
Mol Pharm. 8(4):1113-9 (2011). [PubMed]
Scale-up of In Vitro Permeation Assay Data to Human Intestinal Permeability using Pore Theory.
Kataoka M, Iwai K, Masaoka Y, Sakane T, Sakuma S, Yamashita S.
Int J Pharm. 414(1-2): 69-76 (2011). [PubMed]
Estimation of Michaelis-Menten constant of efflux transporter considering asymmetric permeability.
Sugano K, Shirasaka Y, Yamashita S.
Int J Pharm. 418(2): 161-7 (2011). [PubMed]
Nasal Delivery of P-gp Substrates to the Brain through Nose-brain Pathway.
Shingaki T, Hidalgo IJ, Furubayashi T, Sakane T, Katsumi H, Yamamoto A, Yamashita S.
Drug Metab Pharmacokinet. 26(3):248-55 (2011). [PubMed]
Preparation of spray-dried microparticles using Gelucire 44/14 and porous calcium silicate or spherical microcrystalline cellulose to enhance transport of water-insoluble pranlukast hemihydrate across Caco-2 monolayers
Ozeki T, Takashima Y, Nakano T, Yuasa H, Kataoka M, Yamashita S, Tatsumi T, Okada H.
Advanced Powder Technology 22(5):623-28 (2011). [PubMed]
Impact of microdosing clinical study - Why necessary and how useful?
Sugiyama Y, Yamashita S.
Adv Drug Deliv Rev. 63(7):494-502 (2011). [PubMed]
Enteric-coated tablets improve oral bioavailability of DX-9065, a novel anticoagulant.
Fujii Y, Kanamaru T, Kikuchi H, Yamashita S, Sakuma S.
Eur J Pharm Sci. 42(4):392-9 (2011).. [PubMed]
A potential of peanut agglutinin-immobilized fluorescent nanospheres as a safe candidate of diagnostic drugs for colonoscopy
Sakuma S, Kataoka M, Higashino H, Yano T, Masaoka Y, Yamashita S, Hiwatari K, Tachikawa H, Kimura R, Nakamura K, Kumagai H, Gore JC, Pham W.
Eur J Pharm Sci. 42(4):340-347 (2011). [PubMed]
Coaxial Electrospray Formulations for Improving Oral Absorption of a Poorly Water-Soluble Drug.
Zhang S, Kawakami K, Yamamoto M, Masaoka Y, Kataoka M, Yamashita S, Sakuma S.
Mol Pharm. 8(3):807-13 (2011). [PubMed]
2010
In Vitro Dissolution/Permeation System to Predict the Oral Absorption of Poorly Water-Soluble Drugs: Effect of Food and Dose Strength on It.
Kataoka M, Itsubata S, Masaoka Y, Sakuma S, Yamashita S.
Biol Pharm Bull. 34(3):401-407 (2011). [PubMed]
PET Imaging of gastrointestinal absorption process of orally administered
drugs using positron emission tomography.
Yamashita S, Takashima T, Kataoka M, Oh H, Sakuma S, Takahashi M, Suzuki N, Hayashinaka E, Wada Y, Cui Y, Watanabe Y.
J Nucl Med. 52(2):249-56 (2011). [PubMed]
IVIVR in oral absorption for fenofibrate immediate release tablets using dissolution and dissolution permeation methods.
Buch P, Holm P, Thomassen JQ, Scherer D, Kataoka M, Yamashita S, Langguth P.
Pharmazie. 66(1):11-6 (2011). [PubMed]
Transnasal Delivery of Methotrexate to Brain Tumors in Rats: A New Strategy for Brain Tumor Chemotherapy.
Shingaki T, Inoue D, Furubayashi T, Sakane T, Katsumi H, Yamamoto A, Yamashita S.
Mol Pharm. 7(5):1561-68 (2010). [PubMed]
Quantitative Analysis of the Effect of Supersaturation on in Vivo Drug Absorption.
Takano R, Takata N, Saito R, Furumoto K, Higo S, Hayashi Y, Machida M, Aso Y, Yamashita S.
Mol Pharm. 7(5):1431-40 (2010). [PubMed]
2009
Mechanisms of membrane transport of poorly soluble drugs: role of micelles in oral absorption processes.
Yano K, Masaoka Y, Kataoka M, Sakuma S, Yamashita S.
J Pharm Sci. 99(3):1336-45 (2010). [PubMed]
Detection of early colorectal cancer imaged with peanut agglutinin-immobilized fluorescent nanospheres having surface poly(N-vinylacetamide) chains.
Sakuma S, Yano T, Masaoka Y, Kataoka M, Hiwatari K, Tachikawa H, Shoji Y, Kimura R, Ma H, Yang Z, Tang L, Hoffman RM, Yamashita S.
Eur J Pharm Biopharm. 74(3):451-60 (2010). [PubMed]
Carboxyl group-terminated polyamidoamine dendrimers bearing glucosides inhibit intestinal hexose transporter-mediated D-glucose uptake.
Sakuma S, Teraoka Y, Sagawa T, Masaoka Y, Kataoka M, Yamashita S, Shirasaka Y, Tamai I, Ikumi Y, Kida T, Akashi M.
Eur J Pharm Biopharm. 75(3):366-74 (2010). [PubMed]
Oligoarginine-linked polymers as a new class of penetration enhancers.
Sakuma S, Suita M, Masaoka Y, Kataoka M, Nakajima N, Shinkai N, Yamauchi H, Hiwatari K, Tachikawa H, Kimura R, Yamashita S.
J Control Release. 148(2):187-96 (2010). [PubMed]
Prediction of food effect by bile micelles on oral drug absorption considering free fraction in intestinal fluid.
Sugano K, Kataoka M, Mathews Cda C, Yamashita S.
Eur J Pharm Sci. 40(2):118-24 (2010). [PubMed]
A theoretical-empirical analysis on the initial dissolution rate of drugs from polydispersed particles.
Takano R, Takata N, Shiraki K, Higo S, Hayashi Y, Yamashita S.
Biol Pharm Bull. 32(11):1885-91 (2009). [PubMed]
Correlation between in vitro dissolution profiles from enteric-coated dosage forms and in vivo absorption in rats for high-solubility and high-permeability model drugs.
Sakuma S, Ogura R, Masaoka Y, Kataoka M, Tanno FK, Kokubo H, Yamashita S.
J Pharm Sci. 98(11):4141-52 (2009). [PubMed]
IVIVC in oral absorption for fenofibrate immediate release tablets using a dissolution/permeation system.
Buch P, Langguth P, Kataoka M, Yamashita S.
J Pharm Sci. 98(6):2001-9 (2009). [PubMed]
2008
Stabilization of enzyme-susceptible glucoside bonds of phloridzin through conjugation with poly(gamma-glutamic acid).
Sakuma S, Sagawa T, Masaoka Y, Kataoka M, Yamashita S, Shirasaka Y, Tamai I, Ikumi Y, Kida T, Akashi M.
J Control Release. 133(2):125-31 (2009). [PubMed]
The transnasal delivery of 5-fluorouracil to the rat brain is enhanced by acetazolamide (the inhibitor of the secretion of cerebrospinal fluid).
Shingaki T, Hidalgo IJ, Furubayashi T, Katsumi H, Sakane T, Yamamoto A, Yamashita S.
Int J Pharm. 30;377(1-2):85-91 (2009). [PubMed]
Analysis of risk factors in human bioequivalence study that incur bioinequivalence of oral drug products.
Yamashita S, Tachiki H.
Mol Pharm. 6(1):48-59 (2009). [PubMed]
In vitro/in vivo biorecognition of lectin-immobilized fluorescent nanospheres for human colorectal cancer cells.
Sakuma S, Yano T, Masaoka Y, Kataoka M, Hiwatari K, Tachikawa H, Shoji Y, Kimura R, Ma H, Yang Z, Tang L, Hoffman RM, Yamashita S.
J Control Release. 134(1):2-10 (2009). [PubMed]
Site-specific drug delivery to the middle-to-lower region of the small intestine reduces food-drug interactions that are responsible for low drug absorption in the fed state.
Tanno FK, Sakuma S, Masaoka Y, Kataoka M, Kozaki T, Kamaguchi R, Ikeda Y, Kokubo H, Yamashita S.
J Pharm Sci. 97(12):5341-53 (2008). [PubMed]
Rate-limiting steps of oral absorption for poorly water-soluble drugs in dogs; prediction from a miniscale dissolution test and a physiologically-based computer simulation.
Takano R, Furumoto K, Shiraki K, Takata N, Hayashi Y, Aso Y, Yamashita S.
Pharm Res. 25(10):2334-44 (2008). [PubMed]
Site-specific drug delivery to the middle region of the small intestine by application of enteric coating with hypromellose acetate succinate (HPMCAS).
Tanno FK, Sakuma S, Masaoka Y, Kataoka M, Kozaki T, Kamaguchi R, Ikeda Y, Kokubo H, Yamashita S.
J Pharm Sci. 97(7):2665-79 (2008). [PubMed]
Scaling of in vitro membrane permeability to predict P-glycoprotein-mediated drug absorption in vivo.
Shirasaka Y, Masaoka Y, Kataoka M, Sakuma S, Yamashita S.
Drug Metab Dispos. 36(5):916-22 (2008). [PubMed]