＜研究業績＞
2024年
Nakao T, Yuzuriha T, Kakutani H; An accurate analytical method based on gas chromatography-mass spectrometry for quantifying all oleic, linoleic, and linolenic acid isomers, including trans-form and cis-trans-mixedisomers, in food ., Microchemical Journal, 208, 112443, 2025.

Nakao T, Yuzuriha T, Kakutani H; Benzotriazole ultraviolet absorber contamination in breast milk and the infant health risk., BPB reports, 7, 2, 61-5, 2024.

Kakutani H, Yuzuriha T, Nakao N; Breast milk-mediated exposure to dioxins and antigen in infancy enhances antigen-specific antibody production capacity in adulthood in mice., The Journal of Toxicological Sciences, 49, 5, 209-18, 2024.

2022年
Nakao T, Kakutani H, Yuzuriha T, Ohta S; Distribution, Metabolism, Excretion, and Lactational Transfer to Pups of Tetrabromobisphenol A and Its Metabolites in C57BL/6 Mice., BPB reports, 5, 50-8, 2022.

2021年
Kakutani H, Yuzuriha T, Nakao N, Ohta S; Long-term orally exposure of dioxins affects antigen-specific antibody production in mice., Toxicology Reports, 9, 53-7, 2021.

2019年
Miyachi H, Yuzuriha T, Tabata R, Fukuda S, Nunomura K, Bangzhong Lin, Kobayashi T, Ishimoto K, Doi T, Tachibana K; Structural Development of 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic Acid Derivatives as Human Peroxisome Proliferator-Activated Receptor Alpha (PPARα)-selective Agonists., Bioorganic & Medicinal Chemistry Letters, 29, 2124-8, 2019.

Tachibana K, Ishimoto K, Takahashi R, Kadono H, Awaji T, Yuzuriha T, Tanaka T, Hamakubo T, Sakai J, Kodama T, Aoki S,i Doi T; Development of a Ligand Screening Tool Using Full-Length Human Peroxisome Proliferator-Activated Receptor-Expressing Cell Lines to Ameliorate Metabolic Syndrome., Chemical and Pharmaceutical Bulletin, 67, 199-202, 2019.

中尾晃幸, 薬毒物代謝酵素と環境汚染物質の代謝活性化, 30, 186-93, 廃棄物資源循環学会誌.

2018年
Kakutani H, Yuzuriha T, Nakao T,Ohta S; Complex toxicity as disruption of adipocyte or osteoblast differentiation in human mesenchymal stem cells under the mixed condition of TBBPA and TCDD., Toxicology Reports, 5, 737-43, 2018.

Tachibana K, Yuzuriha T, Tabata R, Fukuda S, Maegawa T, Takahashi R, Yanimoto K, Tsujino H, Nunomura K, Banghong Lin, Matsuura Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Kobayashi T, Ishimoto K, Miyachi H, Doi T; Discovery of peroxisome proliferator-activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line., Journal of Biological Chemistry,  293, 10333-43, 2018.

2015年
Akiyama E, Kakutani H, Nakao T, Motomura Y, Takano Y, Sorakubo R, Mizuno A, Aozasa O, Tachibana K, Doi T, Ohta S; Facilitation of adipocyte differentiation of 3T3-L1 cells by debrominated tetrabromobisphenol A compounds detected in Japanese breast milk., Environmental Research, 140, 157-64, 2015.

Kakutani H, Aozasa O, Akiyama E, Nakao T, Ohta S; Property of cytochrome P450 1A inducibility by polychlorinated/brominated biphenyls (Co-PXBs) detected in Japanese breast milk. Toxicology Reports, 2, 685-91, 2015.

Nakao T, Akiyama E, Kakutani H, Mizuno A., Aozasa O, Akai Y, Ohta S; Contamination levels of tetrabromobisphenol A, tribromobisphenol A, dibromobisphenol A, monobromobisphenol A and bisphenol A in Japanese breast milk., Chemical Research in Toxicology, 28, 722- 8, 2015.

Nakao T, Akiyama E, Kakutani H, Mizuno A., Aozasa O, Akai Y, Ohta S; Detection of tribromobisphenol A as debrominated compounds of tetrabromobisphenol A in breast milk collected in Japan., Journal of Environmental Chemistry, 25, 69-77, 2015.

2014年
Kakutani H, Aozasa O, Mizuno A, Akiyama E, Nakao T, Ohta S; In vitro and in vivo induction of cytochrome P450 by coplanar polychlorinated/brominated biphenyls (Co-PXBs) providing high TEQ in mother's milk in Japan., Toxicology, 324, 68-75, 2014.

2012年
Suzuki H, Kondoh M, Kakutani H, Yamane S, Uchida H, Hamakubo T, Yagi K; The application of an alanine-substituted mutant of the C-terminal fragment of Clostridium perfringens enterotoxin as a mucosal vaccine in mice., Biomaterials, 33, 317-24, 2012

2011年
Kakutani H, Takahashi A, Kondoh M, Saito Y, Yamaura T, Sakihama T, Hamakubo T, Yagi K; A novel screening system for claudin binder using baculoviral display., PLos One, 6, e16611, 2011.

Gomara B, Herrero L, Pacepavicius G, Ohta S, Alaee M, Gonzalez MJ; Occurrence of co-planar polybrominated/chlorinated biphenyls (PXBs), polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in breast milk of women from Spain., Chemosphere, 83, 799-805, 2011.

2010年
Suzuki H, Kakutani H, Kondoh M, Watari A, Yagi K; The safety of a mucosal vaccine using the C-terminal fragment of Clostridium perfringens enterotoxin A., Pharmazie, 65, 766-9, 2010.

Saeki R, Kondoh M, Kakutani H, Matsuhisa K,Takahashi A, Suzuki H, Kakamu Y, Watari A, Yagi K; A claudin-targeting molecule as an inhibitor of tumor metastasis., The Journal of Pharmacology and Experimental Therapeutics, 334, 576-82, 2010.

Kakutani H, Kondoh M, Saeki R, Fujii M, Watanabe Y, Mizuguchi H, Yagi K; Claudin-4-targeting of diphtheria toxin fragment A using a C-terminal fragment of Clostridium perfringens enterotoxin., 75, 213-7, 2010.

Kakutani H, Kondoh M, Fukasaka M, Suzuki H, Hamakubo T, Yagi  K; Mucosal vaccination using claudin-4-targeting., Biomaterials, 31, 5463-71, 2010.


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