研究業績
学術論文
2022年
Tsuji, T., Hosoda, A., Toriyama, Y., Yoshida, Y., Kohno, T.:Renin-angiotensin system inhibitors combined with cisplatin exacerbate cisplatin-induced nephrotoxicity in mice. Elsevier , doi: 10.1016/j.tranon.2022., Published online Apr. 4, 2022
Yoshida, Y., Banno-Terada, R., Takada, M., Fujii, T., Takagaki, N., Maekawa, A., Tanaka, A., Endo, M., Yamada, A., Mamiya, R., Nagi-Miura, N., Ohno, N., Tsuji, T., Kohno, T.:Sivelestat's effect on Candida albicans water-soluble fraction-induced vasculitis. Pediatrics International, doi: 10.1111/ped.15153, Published online Jan. 28, 2022
2021年
Yoneda, K., Fujii, M., Imaoka, A., Kobayashi, R., Hayashi R., Yoshida, Y., Kohno, T., Tsuji, T.:Preventive effect of edaravone ointment on cyclophosphamide-chemotherapy induced alopecia．Support Care Cancer , doi: 10.1007/s00520-021-06189-7, Published online Apr. 2, 2021
辻琢己，倉本展行，安原智久，西田健太朗，久家貴寿：完全遠隔型プログラムによる臨床マインド育成の試み. 薬学教育, doi:10.24489/jjphe.2020-057, Published online Jan. 30, 2021
Nagata, M., Yasuhara, T., Kushihata, T., Ueda, A., Kurio, W., Sone, T., Kohno, T.: Construction of a Practical Disaster Prevention Drill Including the Operation of Temporary Disaster Shelters and Rescue Centers at the University and Application in Disaster Medical Education. Jpn. J. Pharm. Edu., doi:10.24489/jjphe.2020-043, Published online Feb. 19, 2021.
Yoshida, Y., Mikami, N., Nakanishi, Y., Saimoto, M., Nagaike, A., Shimono, H., Nakano, S., Tsuji, T., Kohno, T.: Characterization of an Expanded IL-10-Producing-Suppressive T cell Population Associated with Immune Tolerance. Biol. Phar. Bull., doi:10.1248/bpb.b19-01072, Published online Jan. 26, 2021.
2020年
Hosoda, A., Matsumoto, Y., Toriyama, Y., Tsuji, T., Yoshida, Y., Masamichi S., Kohno, T.: Telmisartan Exacerbates Cisplatin-Induced Nephrotoxicity in a Mouse Model. Biol. Pharm. Bull., 43(9), 1331-1337, 2020.
Ogushi, S., Yoshida, Y., Nakanishi, T., Kimura, T.: CpG Site-Specific Regulation of Metallothionein-1 Gene Expression. Int J Mol Sci., doi:10.3390/ijms21175946, Published online Aug. 19, 2020.
岩﨑綾乃，曽根知道，奥村秀二，牧亮太，河野武幸：B型肝炎ウイルス感染患者が薬学生の学びを支援する学習方略：学びが患者への共感とリンクし深化する患者参加型教育．YAKUGAKU ZASSHI, 140(10), 1275-1284, 2020.
2019年
大坪達弥，河村佳奈，岸本翔，眞釼彩子，小林大祐，江島智彦，辻琢己，菊田真穂，村木優一，河野武幸，隄康彦，魚嶋伸彦，友金幹視：ダカルバジンによる血管痛にザルトプロフェンが著効した１症例．日病薬誌, 55(6), 649-652, 2019.
吉田侑矢，河野武幸：免疫抑制薬フィンゴリモド（FTY720）を用いた免疫寛容誘導．臨床免疫・アレルギー科, 71(5), 508-514, 2019
亀田直子，鎌田佳奈美，池田友美，菊田真穂，山本十三代，辻琢己：小児病棟での統合看護学実習における薬学部生との専門職連携教育の実践報告．摂南大学看護学研究，7(1), 12-19, 2019.
森谷利香，鎌田佳奈美，辻琢己，岩﨑綾乃，眞島崇：看護学部生・薬学部生による多職種連携教育の一環としての「患者安全」に関する実践報告 −協同授業を通した看護学生のイメージ変化−．摂南大学看護学研究，7(1), 20-27, 2019.
2018年
Tsuji, T., Hattori, Y., Komori, K., Yoshida, Y., Banno, R., Kohno, T.: Intravenous Lipid Emulsion Therapy for Acute Clomipramine Intoxication in Rats. Acute Med. Surg., 5(3), 272-277, 2018.
小森浩二，安原智久，曾根知道，河野武幸：事前学習と実務実習の総合的評価の確率に向けて〜卒業時における臨床能力の質保証のために〜．薬学教育, 2, 17-22, 2018.
2017年
辻琢己，大坪達弥，河野武幸：ダカルバジンによる血管痛を抑制できる前投薬医薬品．BIO Clin., 32(11), 62-64, 2017.
大坪達弥，辻琢己，梅山貴生，首藤みほ，米須香那，松本美菜子，吉田侑矢，坂野理絵，友金幹視，藤田敦夫， 河野武幸，三上正：ダカルバジン投与における血管痛対策の検討．YAKUGAKU ZASSHI, 137(3): 363-369, 2017.
2016年
Tsuji, T., Okuno, S., Kuroda, A., Hamazaki, J., Chikami, T., Sakurai, S., Yoshida, Y., Banno, R., Fujita, T., Kohno, T.: Therapeutic Approach to Mite-induced Intractable Dermatitis Using Novel Immunomodulator FTY720 Ointment (Fingolimod) in NC/Nga Mice. Allergol. Int., 65, 172-179, 2016.
Yoshida, Y., Mikami, N.,Matsushima, Y., Miyawaki, M., Endo, H., Banno, R., Tsuji, T., Fujita, T., Kohno, T.: Combination Treatment with Fingolimod and a Pathogenic Antigen Prevents Relapse of Glucose-6-phasphate Isomerase Peptide-induced Arthritis. Immun. Inflamm. Dis., 4(3), 263-273, 2016.
喜田孝史，中嶋尚子，岡庭暁子，辻琢己，河田興：向精神薬服用妊婦における周産期管理状況調査．日本小児臨床薬理学会雑誌, 29, 25-29, 2016.
小森浩二，片岡誠，倉本展行，辻琢己，中谷尊史，安原智久，三田村しのぶ，塙由美子，荻田喜代一：長期実務実習終了学生に対するアドバンスト臨床能力試験の実施による実習成果の実証．YAKUGAKU ZASSHI, 136(9), 1275-1284, 2016.
2015年
安原智久，曽根知道，河野武幸，荻田喜代一:パフォーマンス評価を志向した修正版グラウンデッド・セオリー・アプローチによる卒業研究の概念抽出とRubric作成．薬学雑誌, 135(1), 99-105, 2015.
安原智久，曽根知道，小西元美，串畑太郎，西川智絵，山本祐実，栗尾和佐子，河野武幸: 方略としてのKJ法とWorld Caféがもたらす学習効果の比較-テキストマインニングを用いた考察-．薬学雑誌, 135(5), 753-759, 2015.
安原智久，河野武幸，荻田喜代一：ディプロマ・ポリシーに基づくパフォーマンス評価とルーブリック．ファルマシア, 51(2), 143-148, 2015.
Yoshida, Y., Mikami, N., Tsuji, T., Takada, Y., Nakazawa, Y., Dan, R., Takatsuji, M., Fujita, T., Tsujikawa, K., Kohno, T.: Mechanism of Induction of Immune Tolerance in Experimental Autoimmune Encephalomyelitis by Combination Treatment with Fingolimod Plus Pathogenic Autoantigen. Clin. Exp. Neuroimmunol., 6, 49-56, 2015.
吉村友里，中尾元紀，上野裕之，玉田太志，赤尾昌治，辻琢己，河野武幸，北村良雄：院内ガイドライン作成による周術期の抗血栓薬の取扱いの標準化．日病薬誌, 51(3), 305-309, 2015.
Yoshida, Y., Mikami, N.,Matsushima, Y., Otani, F., Miyawaki, M., Takatsuji, M., Banno, R., Tsuji, T., Fujita, T., Tsujikawa, K., Kohno, T.: Functional Mechanism(s) of the Inhibition of Disease Progression by Combination Treatment with Fingolimod Plus Pathogenic Antigen in a Glucose-6-phasphate Isomerase Peptide-induced Arthritis Mouse model. Biol. Pharm. Bull., 38(8), 1120-1125, 2015.
辻琢己: 難治性アトピー性皮膚炎に対する新規治療方法（フィンゴリモド外用療法）の開発. アレルギーの臨床, 35(10): 54-58, 2015.
2014年
板倉勲子，安原智久，辻琢己，阪上由美，山本裕子，森谷利香，山本智津子，村松十和，奥野智史，木村朋紀，中尾晃幸，河野武幸，後閑容子，荻田喜代一: 看護学部-薬学部専門職連携教育の取組について．摂南大学看護学研究, 2(1), 57-67, 2014.
藤多哲朗，河野武幸: フィンゴリモド（FTY720）の開発と将来展望．医学のあゆみ, 251(2), 191-196, 2014.
辻琢己，大坪達弥，梅山貴生，首藤みほ，米須香那，松本美菜子，吉田侑矢，坂野理絵，三上正，河野武幸: ダカルバジン投与時に生じる血管痛の抑制を目的とした投与方法．薬学雑誌, 134(9), 981-986, 2014.
栗尾和佐子，小西元美，奥野智史，中尾晃幸，木村朋紀，辻琢己，山室晶子，山本祐実，西川智絵，柳田一夫，安原智久，河野武幸，荻田喜代一，曽根知道: 自己研鑽・参加型キャリア形成教育プログラム：「薬系インターンシップ・ボランティア体験実習」-受講３年後の追跡調査から検証した体験実習の効果．薬学雑誌, 134(11), 1199-1208, 2014.
2013年
辻琢己，吉田侑矢，河野武幸: フィジカルアセスメント実習は薬学生の意識を変革する．医学教育, 44(3), 121-131, 2013.
Yoshida, Y., Tsuji, T., Watanabe, S., Matsushima, A., Matsushima, Y., Banno, R., Fujita, T., Kohno, T.: Efficacy of Combination Treatment with Fingolimod (FTY720) Plus Pathogenic Autoantigen in a Glucose-6-phsophate Isomerase Peptide (GPI325-339)-Induced Arthritis Mouse Model. Biol. Pharm. Bull., 36(11), 1739-1746, 2013.
2012年
Tsuji, T., Inoue, M., Yoshida, Y., Fujita, T., Kaino, Y., Kohno, T.: Therapeutic Approach for Type-1 Diabetes Mellitus Using the Novel Immunomodulator FTY720 (Fingolimod) in Combination with Once-daily Injection of Insulin Glargine in Non-obese Diabetic Mice. J. Diabetes Invest., 3(2), 132-137, 2012.
Tsuji, T., Yoshida, Y., Fujita, T., Kaino, Y., Kohno, T.: Oral Therapy for Type-1 Diabetes Mellitus a Novel Immunomodulator, FTY720 (Fingolimod), in Combination with Sitagliptin, a Dipeptidyl Peptidase-4 Inhibitor, Examined in Non-obese Diabetic Mice. J. Diabetes Invest., 3(5), 441-448, 2012.
辻琢己，吉田侑矢，藤多哲朗，河野武幸: ダニ抗原誘発性難治性皮膚炎に対する新規免疫調節薬FTY720とベタメタゾン軟膏併用療法の有用性：NC/Ngaマウスを用いた検討．アレルギー, 61(7), 948-958, 2012.
栗尾和佐子，小西元美，奥野智史，中尾晃幸，辻琢己，山室晶子，吉田侑矢，山本祐実，西川智絵，安原智久，柳田一夫，中村三孝，曾根知道，河野武幸，荻田喜代一，前田定秋：自己研鑽・参加型キャリア形成教育プログラム「薬系インターンシップ・ボランティア体験学習」とその効果．医療薬学，38(12), 757-766, 2012
2011年
辻琢己，井上真理子，大塚源太郎，松田裕子，屋良龍輝，渡辺雄太，吉田侑矢，河野武幸: Effectiveness of A Novel Immunomodulator, FTY720 (Fingolimod), on Type-1 Diabetes Mellitus. Clinical Pharmacology and Therapy., 21(2), 69-74, 2011.
辻琢己，加藤雄勢，三井香奈，仲谷芙美，渡邉紘史，吉田侑矢，河野武幸: Effectiveness of A Novel Immunomodulator, FTY720 (Fingolimod), on Atopic Dermatitis. Clinical Pharmacology and Therapy., 21(2), 75-79, 2011.
吉田侑矢，岩槻瑠美，箱部広樹，樋口佐恵，吉村恭太，米村聡朗，辻琢己，河野武幸: Effectiveness of A Novel Immunomodulator, FTY720 (Fingolimod), on Autoimmune Neurological Disorders. Clinical Pharmacology and Therapy., 21(2), 81-89, 2011.
Yoshida, Y., Tsuji, T., Fujita, T., Kohno, T.: Relapse of Experimental Autoimmune Encephalomyelitis after Discontinuation of FTY720 (Fingolimod) Treatment, but Not after Combination of FTY720 and Pathogenic Autoantigen. Biol. Pharm. Bull., 34(6), 933-936, 2011.
吉田侑矢，辻琢己，細田敦規，河野武幸，久保貞也，佐竹正人，難波洋，瀬野智美，前田定秋: 実地臨床に従事する薬剤師参加型のセルフメディケーション演習の有用性. 医療薬学，38(5), 288-298, 2012.
Tsuji, T., Yoshida, Y., Iwatsuki, R., Inoue, M., Fujita, T., Kohno, T.: Therapeutic Approach to Steroid-Resistant Dermatitis Using Novel Immunomodulator FTY720 (Fingolimod) in Combination with Betamethasone Ointment in NC/Nga Mice. Biol. Pharm. Bull., 35(8), 1314-1319, 2011.
2010年
田中祥之，岡野由貴，吉田侑矢，辻琢己，河野武幸: イムノアッセイによるセラペプターゼの定量法開発とバリデーション. 生物試料分析, 33, 260-266, 2010.
2006年
Matsumoto, N., Uchida, S., Kohno, T., Shimizu, T., Kusumoto, H., Hirose, R., Yanada, K., Kurio, W., Yamaguchi, S., Watabe, K., Fujita, T.: Preparation of Antibodies Against A Novel Immunosuppressant, FTY720, and Development of An Enzyme Immunoassay for FTY720. J. Med. Chem., 14, 4182-4192, 2006.
Shirahama, T., Kohno, T., Kajima, T., Nagaoka, Y., Morimoto, D., Hirata, K., Uesato, S.: Stereoselective Conversion of Anhydrovinblastine into Vinblastine Utilizing an Anti-vinblastine Monoclonal Antibody as a Chiral Mould. Chem. Pharm. Bull., 54(5), 665-668, 2006.
2005年
Kohno, T., Tsuji, T., Hirayama, K., Iwatsuki, R., Hirose, M., Watabe, K., Yoshikawa, H., Kohno, T., Matsumoto, A., Fujita, T., Hayashi, M.: A Novel Immunomodulator, FTY720, Prevents Development of Experimental Autoimmune Myasthenia Gravis in C57BL/6 Mice. Biol. Pharm. Bull., 28, 736-739, 2005.
2004年
河野武幸, 辻琢巳, 平山かおり, 岩槻瑠美, 廣瀬道隆, 渡部一仁, 吉川弘明, 渡部一仁, 渡部一仁, 林正俊: 重症筋無力症に対する新規免疫抑制剤FTY720の薬効・薬理試験：EAMGマウスを用いた検討. Neuroimmunology, 12, 59, 2004.
Kohno, T., Tsuji, T., Hirayama, K., Watabe, K., Matsumoto, A., Kohno, T., Fujita, T.: A Novel Immunomodulator, FTY720, Prevents Spontaneous Dermatitis in NC/Nga Mice. Biol. Pharm. Bull., 27, 1392-1396, 2004.
Kohno, T., Hirayama, K., Iwatsuki, R., Hirose, M., Watabe, K., Yoshikawa, H., Matsumoto, A., Kohno, T., Fujita, T., Hayashi, M.: A Drug Candidate for Treatment of Myasthenia Gravis: Efficacy of a Novel Immunosuppressant FTY720 in Experimental Autoimmune Myasthenia Gravis. J. Neuroimmunol., 154, 153, 2004.
2003年
河野武幸, 辻琢巳, 平山かおり, 渡部一仁, 渡部一仁, 林正俊: 実験的重症筋無力症モデルマウスのTh1/Th2サイトカインmRNA産生量と新規免疫抑制剤（FTY720）の影響. Neuroimmunology, 11, 103, 2003.
2002年
Kohno, T., Kobashiri, Y., Sugie, Y., Takai, S., Watabe, K., Kaino, Y., Kida, K.: Antibodies to Food Antigens in Japanese Patients with Type-1 Diabetes Mellitus. Diabetes Res. Clin. Prac., 55, 1-9, 2002.
2001年
河野武幸, 杉江陽子: カルシトニンの測定法と血中濃度. in “カルシウムと骨”（西井易穂，森井浩世，江沢郁子，小島至，編）, 2001, pp281-285, 朝倉書店（東京，日本）.
Fujita, T., Izumo,N., Fukuyama, R., Meguro, T., Nakamuta, H., Kohno, T., Koida, M.: Phosphate Provides an Extracellular Signal that Drives Nuclear Export of Runx2/Cbfa1 in Bone Cells. Biochem. Biophys. Res. Commun., 280, 348-252, 2001.
林正俊，河野武幸，剣持一美: 重症筋無力症患者におけるCD4陽性ヘルパーTサブセットについて. Neuroimmunology, 9, 88-89, 2001.
Kohno, T., Tsuji, T., Watabe, K., Hayashi, M.: Differences in Susceptibility to Development of Experimental Myasthenia Gravis in C57BL/6 and Balb/c Mouse. J. Neuroimmunol., 118, 157, 2001.
2000年
Fujita, T., Matsumoto, N., Uchida, S., Kohno, T., Shimizu, T., Hirose, R., Yanada, K., Kurio, W., Watabe, K.: Antibody Against a Novel, Myriosin (ISP-I)-Based Immunosuppressant, FTY720. Bioorganic Medicinal Chem. Lett., 10, 337-339, 2000.
Furuichi, H., Fukuyama, R., Izumo, N., Fujita, T., Kohno, T., Nakamuta, H., Koida, M.: Bone-Anabolic Effect of Salmon Calcitonin in Glucocorticoid-Induced Osteopenia in Rats. Biol. Pharm. Bull., 23, 946-951, 2000.
1999年
Kohno, T., Tanaka, H., Watabe, K., Yamashita, S., Sezaki, H., Nadai, T., Sugie, Y., Ogouchi, T.: Assessment of Mucosal Immune Response in Genitourinary Tract Using Urine. Microbiol. Immunol., 43, 253-258, 1999.
1998年
Kohno, T., Murasugi, N., Sakurai, H., Watabe, K., Nakamuta, H., Kioda, M., Sugie, Y., Nomura, M., Yanagawa, A.: Development of a Highly Sensitive and Specific Two-Site Enzyme Immunoassay for Parathyroid Hormone (1-34): Application to Pharmacokinetic Study on Intranasal Parathyroid Hormone (1-34) in Human. J. Clin. Lab. Anal., 12, 268-275, 1998.
Nakamura, M., Tsume, Y., Nadai, T., Sezaki, H., Kohno, T., Tabata, Y., Yamashita, S.: Potential Efficiency of Gelatin Microspheres as a New Adjuvant for Oral Vaccination. S.T.P. Pharma. Sci., 8, 67-73, 1998.
Hayashi, M., Kohno, T., Yoshinaga, J., Kida, K.: Epitope Analysis of AChR Ab in Patients with Myasthenia Gravis using Sensitive Enzyme Immunoassay. Ann. NY Acad. Sci., 841, 478-481, 1998.
Kohno, T., Ikeuchi, S., Tachiki, S., Kobashiri, Y., Watabe, K., Sugie, Y., Yoshinaga, J., Kida, K., Hayashi, M.: HLA-DQB1-DRB1 Haplotype and Its Relation to Polyclonarity of Acetylcholine Receptor Autoantibody in Japanese Patients with Myasthenia Gravis. J. Neuroimmunol., 90, 91, 1998.
Kohno, T., Murasugi, N., Sakurai, H., Watabe, K., Nakamuta, H., Koida, M., Sugie, Y., Ogouchi, T., Inoue, T., Yanaka, M., Nomura, M., Yanagawa, A.: Determination of the Bioavailability of Intranasal Elcatonin in Human: Development of a Sandwich Transfer Enzyme Immunoassay for Elcatonin. J. Clin. Lab. Anal., 12, 356-362, 1998.
1997年
Yamazaki, M., Koide, H., Nakao, S., Takamatsu, H., Kohno, T., Watabe, K.: Spore Germinability of Bacillus coagulans and acidophile Baccilus spp. Isolated from Pet-Bottled Tea and Juices. Biocontrol Sci., 2, 27-30, 1997.
Nakamuta, H., Kohno, T., Ichikawa, M., Hoshino, T., Watabe, K., Koida, M.: Plasma Level Monitoring of Nasal Salmon Calcitonin in the Rats by a Heterogeneous Two-Site Enzyme Immunoassay. J. Clin. Lab. Anal., 11, 129-131, 1997.
Kohno, T., Murasugi, N., Sakurai, H., Watabe, K., Nakamuta, H., Koida, M., Sugie, Y., Nomura, M., Yanagawa, A.: A Sandwich Transfer Enzyme Immunoassay for Salmon Calcitonin: Determination of the Bioavailability of Intranasal Salmon Calcitonin in Human. J. Clin. Lab. Anal., 11, 380-387, 1997.
1996年
Nakamura, M., Yamashita, S., Nadai, T., Sezaki, H., Kohno, T., Watabe, K.: Evaluation of Mucosal Immune response as a Barrier against the Oral and Nasal Absorption of Protein Drugs. in “Proceed. Intern. Symp. Control Rel. Bioact. Mater., 23”, 1996, Controlled Release Society, Inc., (U.S.A.).
Tsume, Y., Taki, Y. Sakane, T., Nadai, T., Sezaki, H., Watabe, K., Kohno, T., Yamashita, S.: Quantitative Evaluation of the Gastrointestinal Absorption of Protein into Blood and Lymph Circulation. Biol. Pharm. Bull., 19, 1332-1337, 1996.
Kohno, T., Nakamuta, H., Ichikawa, M., Watabe, K., Koida, M.: A Noncompetitive Enzyme Immunoassay (Hetero-Two-Site Enzyme Immunoassay) for Salmon Calcitonin : Determination of the Bioavailability of Subcutaneous Salmon Calcitonin and Its Correlation with the Hypocalcemic Activity in Rats. J. Clin. Lab. Anal., 10, 91-97, 1996.
Murasugi, N., Sakurai, H., Watabe, K., Nitta, T., Nakamuta, H., Koida, M., Kohno, T.: Development and Applications of Highly Sensitivity Enzyme Immunoassay Methods to Measure Calcitonin and Parathyroid Hormone (PTH (1-34)). J. Bone Miner. Metab., 14, 179, 1996.
1995年
Yukawa, N., Kohno, T., Osawa, M., Saito, T., Nakajima, Y., Ishikawa, E., Takahama, K., Takeichi, S.: Sandwich Capture Enzyme Immunoassay for Water Soluble Blood Group B Substance in Secretor Saliva. J. Immunoassay, 16, 247-261, 1995.
Nakamuta, H., Nitta, T., Hoshino, T., Ichikawa, M., Kohno, T., Watabe, K., Koida, M.: Nasal Salmon Calcitonin : Evaluation of Bioavailability and Anti-Osteoporotic Potency in Rats. Jpn. J. Pharmacol., 67(supple 1), 41P, 1995.
Abe, A., Koide, H., Kohno, T., Watabe, K.: A Bacillus subtilis Spore Coat Polypeptide Gene, cotS. Microbiol., 141, 1433-1442, 1995.
井上忍, 河野武幸, 与儀喜邦, 糸数直哉, 橋田誠一, 石川栄治, 杉本徹: 免疫複合体転移測定法による抗サイログロブリン抗体の測定. 日本小児科学会雑誌, 100, 737-741, 1995.
1994年
Hirota, K., Hashida, S., Hashinaka, K., Kohno, T., Saitoh, A., Shinagawa, H., Nakata, A., Oka, S., Shimada, K., Ishikawa, E.: Sensitive Enzyme Immunoassay (Immune Complex Transfer Enzyme Immunoassay) for antibodies to Reverse Transcriptase (RT) of Human Immunodeficiency Virus Type-1 (HIV-1) Using Recombinant RT of HIV-1 as Antigen. Clin. Chem. Enzym. Comms., 6, 175-184, 1994.
Kaino, Y., Kida, K., Goto, Y., Matsuda, H., Kohno, T., Ishikawa, E.: Thyroglobulin Antibodies in Type 1 Diabetic Patients and Their Relatives-Measured with Highly Sensitive Assay. Diabetes Res. Clin. Practice, 22, 147-154, 1994.
Hashida, S., Hirota, K., Kohno, T., Ishikawa, E.: Anti-HTLV-I IgG in Urine Detected by Sensitive Enzyme Immunoassay (Immune Complex Transfer Enzyme Immuno-assay) Using a Synthetic Peptide, Cys-Env gp46 (188-224), as Antigen. J. Clin. Lab. Anal., 8, 149-156, 1994.
Hashida, S., Hashinaka, K., Saitoh. A., Takamizawa, A., Shinagawa, H., Oka, S., Shimada, K., Hirota, K., Kohno, T., Ishikawa, S., Ishikawa, E.: Diagnosis of HIV-1 Infection by Detection of Antibody IgG to HIV-1 in Urine with Ultrasensitive Enzyme Immunoassay (Immune Complex Transfer Enzyme Immunoassay) Using Recombinant Proteins as Antigens. J. Clin. Lab. Anal., 8, 237-246, 1994.
Ishikawa, S., Hashida, S., Kohno, T., Ishikawa, E.: Use of Microplates and Fluororeader for Ultra-sensitive Enzyme Immunoassay (Immune Complex Transfer Enzyme Immunoassay) of Anti-HTLV-I IgG. J. Clin. Lab. Anal., 8, 327-331, 1994.
小川節子, 鈴木英司, 阿部明子, 河野武幸, 渡部一仁: 河川微生物による化学物質の分解試験およびその分解産物の変異原性について. 衛生化学, 40, 162-170, 1994.
1993年
Hirota, K., Kohno, T., Toshimori, H., Matsukura, S., Hachisu, T., Ishikawa, S, Ishikawa, E.: Detection of Anti-Thyroglobulin Immunoglobulin G in Urine by Sensitive Enzyme Immunoassay (Immune Complex Transfer Enzyme Immunoassay) as a Diagnostic Aid for Autoimmune Thyroid Diseases. Anal. Lett., 21, 17-31, 1993.
Yogi, Y., Hirota, K., Kohno, T., Toshimori, H., Matsukura, S., Setoguchi, T., Ishikawa, E.: Measurement of Anti-Thyroglobulin IgG in Urine of Patients with Autoimmune Thyroid Diseases by Sensitive Enzyme Immunoassay (Immune Complex Transfer Enzyme Immunoassay). J. Clin. Lab. Anal., 7, 70-79, 1993.
Yogi, Y., Kohno, T., Hirota, K., Toshimori, H., Matsukura, S., Setoguchi, T., Ishikawa, E.: Immune Complex Transfer Enzyme Immunoassay for Anti-Thyroglobulin IgG using 2,4-Dinitrophenyl-Thyroglobulin, Biotinyl-Thyroglobulin and Streptavidin-β-D-Galactosidase Conjugate. Anal. Lett., 26, 2143-2159, 1993.
Ishikawa, E., Hashida, S., Kohno, T., Hirota, K., Hashinaka, K., Ishikawa, S.: Principle and Applications of Ultrasensitive Enzyme Immunoassay (Immune Complex Transfer Enzyme Immunoassay) for antibodies in Body Fluids. J. Clin. Lab. Anal., 7, 376-393, 1993.
Abe, A. , Ogawa, S., Kohno, T., Watabe, K.: Purification of Bacillus subtilis Spore Coat Protein by Electrophoretic Elution Procedure and Determination of NH2-Terminal Amino Acid Sequences. Microbiol. Immunol., 37, 809-812, 1993.
1992年
Kaino, Y., Goto, Y., Ikeuchi, M., Ito, T., Kida, K., Matsuda, H., Kohno, T., Ishikawa, E.: Autoantibodies in Japanese Insulin-Dependent Diabetic Patients. in “Recent Progress of Diabetes Mellitus in East Asia” (Mimura, G. and Zhisheng, C., eds.), 1992, pp 73-76, Elsevier Science Publishers B. V. (Amsterdam, Netherlands).
Ishikawa, E., Hashida, S., Kohno, T., Hirota, K.: Ultrasensitive Enzyme Immunoassay. in “Progress in Clinical Biochemistry” (Miyai, K., Kanno, T. and Ishikawa, E. eds.), 1992, pp 213-216, Elsevier Science Publishers B. V. (Amsterdam, Netherlands).
河野武幸, 石川栄治: 抗原抗体反応を利用した超高感度測定法. 蛋白質・核酸・酵素, 37, 144-150, 1992.
Ishikawa, S., Kohno, T., Hashida, S., Ishikawa, E.: Use of Nonspecific F(ab')2 and inactive β-D-Galactosidase to Reduce the Nonspecific Binding of Anti-Ferritin Fab'-β-D-Galactosidase Conjugate in Two-Site Enzyme Immunoassay for Ferritin. Anal. Lett., 25, 695-706, 1992.
広田晃一, 河野武幸, 橋田誠一, 石川栄治: 超高感度酵素免疫測定法. 悩と精神の医学, 3, 83-86, 1992.
Kohno, T., Sakoda, I., Ishikawa, E.: Sensitive Enzyme Immunoassay (Immune Complex Transfer Enzyme Immunoassay) for (Anti-Human T-Cell Leukemia Virus Type I) IgG in Serum Using a Synthetic Peptide, Cys-Env gp46(188-224), as Antigen. J. Clin. Lab. Anal., 6, 105-112, 1992.
Kohno, T., Sakoda, I., Ishikawa, E.: Sensitive Enzyme Immunoassay (Immune Complex Transfer Enzyme Immunoassay) for (Antihuman T-Cell Leukemia Virus Type I) Immunoglobulin G in Serum Using a Synthetic Peptide, Cys-Env gp46 (237-262), as Antigen. J. Clin. Lab. Anal., 6, 162-169, 1992.
Yukawa, N., Kohno, T., Ishikawa, E., Takahama, K.: A Sensitive Sandwich Enzyme Immunoassay for γ-Seminoprotein and Its Application to Sex Discrimination of Blood and Blood Stains. Forensic Sci. Int., 55, 161-172, 1992.
Kohno, T., Hirota, K., Sakoda, I., Yamasaki, M., Yokoo, Y. Ishikawa, E.: Sensitive Enzyme Immunoassay (Immune Complex Transfer Enzyme Immunoassay) for (Anti-Human T-Cell Leukemia Virus Type I) IgG in Serum Using a Recombinant Gag p24 (14-214) as Antigen. J. Clin. Lab. Anal., 6, 302-310, 1992.
1991年
Kohno, H., Kohno, T., Sakoda, I., Ishikawa, E.: Sensitive Detection of Anti-Human T-Cell Leukemia Virus Type I IgG in Human Serum by a Novel Enzyme Immunoassay (Immune Complex Transfer Enzyme Immunoassay) Using Recombinant Gag-Env Hybrid Protein as Antigen. J. Virol. Methods, 31, 77-92, 1991.
Kohno, T., Sakoda, I., Ishikawa, E.: Immune Complex Transfer Enzyme Immunoassay for (Anti-Human T-Cell Leukemia Virus Type I) IgG in Serum Using a Synthetic Peptide, Env GP46(188-209), as Antigen. J. Clin. Lab. Anal., 5, 25-37, 1991.
Hirota, K., Kohno, T., Ishikawa, E.: Simpler and More Sensitive Immune Complex Transfer Enzyme Immunoassay for Anti-Insulin IgG in Serum Using β-D-Galactosidase as Label. Clin. Chem. Enzym. Comms., 4, 27-38, 1991.
Kohno, T., Katsumaru, H., Nakamoto, H., Yasuda, T., Mitsukawa, T., Matsukura, S., Tsunetoshi, Y., Ishikawa, E.: Use of Inactive β-D-Galactosidase for Elimination of Interference by Anti-β-D-Galactosidase Antibodies in Immune Complex Transfer Enzyme Immunoassay for Anti-Thyroglobulin IgG in Serum Using β-D-Galactosidase from Escherichia coli as Label. J. Clin. Lab. Anal., 5, 197-205, 1991.
Kohno, T., Hirota, K., Ishikawa, E.: Presence of Antibodies Against β-D-Galactosidase from Escherichia coli in Serum of Healthy Subjects Examined by Immune Complex Transfer Enzyme Immunoassay. Clin. Chem. Enzym. Comms., 4, 39-49, 1991.
Hirota, K., Kohno, T., Ishikawa, E., Kitamura, T., Tsuda, K., Horiuchi, M., Miura, T.: Detection of Alpha-Fetoprotein from Hepatocellular Carcinoma by Ultrasensitive Two-Site Enzyme Immunoassay After Separation by Affinity Chromatography Using Lens Culinaris Agglutinin-Sepharose 4B. Clin. Chem. Enzym. Comms., 4, 69-76, 1991.
Ishikawa, E., Hashida, S., Kohno, T.: Development of Ultrasensitive Enzyme Immunoassay Reviewed with Emphasis on Factors which Limit the Sensitivity. Mol. Cell. Proves, 5, 81-95, 1991.
Kohno, T., Yuzuriha, T., Hasegawa, J., Ishikawa, E.: Concentration of Hog Elastase I in Serum of Healthy Subjects after Oral Administration Measured by Sensitive Two-Site Enzyme Immunoassay. Clin. Chem. Enzym. Comms., 4, 123-133, 1991.
Kohno, T., Sakoda, I., Suzuki, M., Izumi, A., Ishikawa, E.: Immune Complex Transfer Enzyme Immunoassay for (Anti-Human T-Cell Leukemia Virus Type I) IgG in Serum Using a Synthetic Peptide, Cys-Gag p19 (100-130), as Antigen. J. Clin. Lab. Anal., 5, 307-316, 1991.
石川栄治, 河野武幸: 高感度ＥＩＡ. Oncologia, 24, 97-100, 1991.
Ishikawa, E., Hashida, S., Kohno, T., Hirota, K.: Ultrasensitive Enzyme Immunoassay. Anal. Sci., 7(Suppl), 891-896, 1991.
1990年
Kohno, T., Kitamura, T, Tsuda, K., Ishikawa, E.: Specific Enzyme Immunoassay for α-Fetoprotein from Hepatocellular Carcinoma. J. Clin. Lab. Anal., 4, 74-78, 1990.
Kohno, T., Kitamura, T., Tsuda, K., Ishikawa, E.: Novel and Sensitive Enzyme Immunoassay (Immune-Complex-Transfer Enzyme Immunoassay) for Alpha-Fetoprotein from Hepatocellular Carcinoma. J. Clin. Lab. Anal., 4, 183-188, 1990.
Tanaka, K., Kohno, T., Hashida, S., Ishikawa, E.: Novel and Sensitive Noncompetitive (Two-Site) Enzyme Immunoassay for Haptens with Amino Group. J. Clin. Lab. Anal., 4, 208-212, 1990.
Kohno, T., Mitsukawa, T., Matsukura, S., Ishikawa, E.: Sensitive Time-Resolved Fluorimetric Immune-Complex-Transfer Immunoassay for Anti-thyroglobulin IgG in Serum. J. Clin. Lab. Anal., 4, 224-230, 1990.
河野武幸, 石川栄治: 抗体の新しい超高感度酵素免疫測定法の開発とヒト抗サイログロブリン自己抗体測定への応用. 宮崎医会誌, 14, 15-21, 1990.
河野武幸, 石川栄治: 高感度イムノアッセイ法. BIOmedica, 5, 838-841, 1990.
Kohno, T., Yamaguchi, K., Ishikawa, E.: Immune Complex Transfer Enzyme Immunoassay for Anti-Angiotensin I IgG in Serum Using Angiotensin I Conjugates Prepared by Two Different Methods. J. Biochem., 108, 741-747, 1990.
河野武幸, 石川栄治: 免疫複合体転移測定法による血中抗体の超高感度測定. 宮崎医会誌, 14, 160-164, 1990.
Ishikawa, E., Hashida, S., Kohno, T., Hirota, K.: Ultrasensitive Enzyme Immunoassay. Clin. Chim. Acta, 194, 51-72,1990.
Kohno, H., Kohno, T., Sakoda, I., Ishikawa, E.: Novel and Sensitive Enzyme Immunoassay (Immune-Complex-Transfer Enzyme Immunoassay) for Anti-human T Cell Leukemia Virus Type I IgG in Human Serum Using Recombinant Gag-Env Hybrid Protein as Antigen. J. Clin. Lab. Anal., 4, 355-362, 1990.
1989年
Ishikawa, E., Hashida, S., Tanaka, K., Kohno, T.: Development and Applications of Ultra-sensitive Enzyme Immunoassay for Antigens and Antibodies. in “Highlights Modern Biochemistry. Vol. 2”, 1989, pp 1393-1402, VSP International Science Publishers (Zeist, Netherlands).
Yukawa, N., Kohno, T., Ishikawa, E.: Takahama, K.: A Highly Sensitive and Specific Sandwich Enzyme Immunoassay for Water Soluble A and B Substances. Jpn. J. Legal. Med., 43, 20-26, 1989.
田中弘一郎, 橋田誠一, 河野武幸, 山口賢一, 石川栄治: 新しい酵素免疫測定法によるアンギオテンシンＩの測定. 宮崎医会誌, 13, 11-14, 1989.
Tanaka, K., Hashida, S., Kohno, T., Yamaguchi, K., Ishikawa, E.: Novel and Sensitive Noncompetitive Enzyme Immunoassay for Peptides. Biochem. Biophys. Res. Commun., 160, 40-45, 1989.
Tanaka, K., Hashida, S., Kohno, T., Yamaguchi, K., Ishikawa, E.: Novel and Sensitive Noncompetitive Enzyme Immunoassay to Measure Peptides by Biotinylation. Anal. Lett., 22, 353-363, 1989.
Tanaka, K., Hashida, S., Kohno, T., Mohri, Z., Murakami, Y., Ishikawa, E.: Novel and Sensitive Noncompetitive Enzyme Immunoassay for Kassinin in Rat Plasma. Experientia, 45, 470-472, 1989.
Kohno, T., Mitsukawa, T., Matsukura, S., Tsunetoshi, Y., Ishikawa, E.: More Sensitive and Simpler Immune Complex Transfer Enzyme Immunoassay for Antithyroglobulin IgG in Serum. J. Clin. Lab. Anal., 3, 163-168, 1989.
Ishikawa, E., Hashida, S., Tanaka, K., Kohno, T.: Ultrasensitive Enzyme Immunoassay for Antigens: Technology and Applications - A Review. Clin. Chem Enzym. Comms., 1, 199-215, 1989.
Ishikawa, E., Kohno, T.: Development and Applications of Sensitive Enzyme Immunoassay for Antibodies -A Review. J. Clin. Lab. Anal., 3, 252-265, 1989.
Kohno, T., Mitsukawa, T., Matsukura, S., Tsunetoshi, Y., Ishikawa, E.: Measurement of Anti-Thyroglobulin IgG in Serum by Novel and Sensitive Immune Complex Transfer Enzyme Immunoassay. Clin. Biochem., 22, 277-284, 1989.
Kohno, T., Mitsukawa, T., Matsukura, S., Tsunetoshi, Y., Ishikawa, E.: Anti-Thyroglobulin IgG in Healthy Subjects and Patients with Thyroid Disease Measured by Improved Immune Complex Transfer Enzyme Immunoassay. Clin. Chem. Enzym. Comms., 1, 283-291, 1989.
Ishikawa, E., Hashida, S., Tanaka, K., Kohno, T.: Development and Applications of Ultra-sensitive Enzyme Immunoassay for Antigens and Antibodies. Clin. Chim. Acta, 185, 223-230, 1989.
橋田誠一, 田中弘一郎, 河野武幸, 石川栄治: 酵素免疫測定法の基礎と応用. 生物物理化学, 33, 1-5, 1989.
1988年
Ishikawa, E, Hashida, S., Kohno, T., Tanaka, K.: Labeling of Antigens, Antibodies and Their Fragments. in “Nonisotopic Immunoassay” (Ngo, T. T. ed.), 1988, pp 27-55, Plenum Publishing Corporation (New York, U.S.A.).
河野武幸, 石川栄治: 抗体の新しい高感度酵素免疫測定法とその応用. 宮崎医会誌, 12, 64-69, 1988.
Kohno, T., Ishikawa, E., Sugiyama, S., Nakamura, S.: Novel Enzyme Immunoassay of Anti-Insulin IgG in Human Serum. J. Clin. Lab. Anal., 2,19-24, 1988.
Kohno, T., Ishikawa, E.: Novel Enzyme Immunoassay (Immune Complex Transfer Enzyme Immunoassay) for Anti-Insulin IgG in Guinea Pig Serum. Anal. Lett., 21, 1019-1031, 1988.
Hashida, S., Tanaka, K., Kohno, T., Ishikawa, E.: Novel and Ultra-sensitive Sandwich Enzyme Immunoassay (Sandwich Transfer Enzyme Immunoassay) for Antigens. Anal. Lett., 21, 1141-1154, 1988.
Kohno, T., Mitsukawa, T., Matsukura, S., Ishikawa, E.: Novel Enzyme Immunoassay (Immune Complex Transfer Enzyme Immunoassay) for Anti-Thyroglobulin IgG in Human Serum. J. Clin. Lab. Anal., 2, 209-214, 1988.
Kohno, T., Mitsukawa, T., Matsukura, S., Ishikawa, E.: Novel and Sensitive Enzyme Immunoassay (Immune Complex Transfer Enzyme Immunoassay) for Anti Thyroglobulin IgG in Human Serum. Clin. Chem. Enzym. Comms., 1, 89-96, 1988.
Kohno, T., Tsunetoshi, Y., Ishikawa, E.: Existence of Anti-Thyroglobulin IgG in Healthy Subjects. Biochem. Biophys. Res. Commun., 155, 224-229, 1988.
Kohno, T., Mitsukawa, T., Matsukura, S., Ishikawa, E.: Novel and Sensitive Enzyme Immunoassay for Anti-Thyroglobulin Antibodies in Serum Using Dinitrophenyl Thyroglobulin and Thyroglobulin-Peroxidase Conjugate. Anal. Lett., 21, 2033-2048, 1988.
河野武幸, 石川栄治: 抗体の新しい高感度酵素免疫測定法とその応用. 宮崎医会誌, 12, 177-182, 1988.
1987年
Ishikawa, E., Hashida, S., Kohno, T., Kotani, T., Ohtaki, S.: Modification of Monoclonal Antibodies with Enzymes, Biotin, and Fluorochromes and Their Applications. in “Monoclonal Antibody Production Techniques and Applications” (Schook, L. B. ed.), 1987, pp 113-137, Marcel Dekker, Inc. (New York, U.S.A.).
Ishikawa, E., Hashida, S., Kohno, T., Tanaka, K., Ruan, K-h., Inoue, S.: Enzyme Labeling of Antibodies and Enzyme Immunoassay. In “Cellular, Molecular and Genetic Approaches to Immunodiagnosis and Immunotherapy” (Kano, K., Mori, S., Sugisaki, T. and Torisu, M. eds.), 1987, pp 115-128, University of Tokyo Press (Tokyo, Japan).
Ishikawa, E., Hashida, S., Tanaka, K., Kohno, T.: Sensitive Enzyme Immunoassay for Macromolecular Antigens. in “Proceedings of ROC-Japan Symposium on Biotechnology” (Wei, Y-H. ed.), 1987, pp 29-41, National Science Council, Taipei Taiwan (Republic of China).
Kohno, T., Ishikawa, E., Sugiyama, S., Nakamura, S., Kamano, M., Ichioka, T., Nakajima, K.: Enzyme Immunoassay of Total Insulin in Human Serum Containing Anti-Insulin Antibodies. Clin. Chim. Acta, 163, 105-112, 1987.
Kohno, T., Ishikawa, E., Sugiyama, S., Nakamura, S., Kanemaru, Y.: A Highly Sensitive Enzyme Immunoassay of Anti-Insulin Antibodies in Human Serum. J. Clin. Lab. Anal., 1, 170-174, 1987.
Hashida, S., Tanaka, K., Kohno, T., Ishikawa, E., Umehashi, H., Hayashida, T., Mori, T., Imura, H., Ogawa, H.: A Highly Sensitive Sandwich Enzyme Immunoassay of Human Thyroid-Stimulating Hormone in Dried Blood on Filter Paper Discs for Mass-Screening of Neonatal Hypothyroidism. J. Clin. Lab. Anal., 1, 198-204, 1987.
Kohno, T., Ishikawa, E., Sugiyama, S., Kamano, M., Kuzuya, H., Imura, H.: A Highly Sensitive Enzyme Immunoassay of Anti-Insulin Antibodies in Human Serum. Clin. Chim. Acta, 168, 97-107, 1987.
Yukawa, N., Kohno, T., Ishikawa, E., Takahama, K.: A Highly Specific and Sensitive Sandwich Enzyme Immunoassay for Human Hemoglobin A. Forensic Sci. Int., 35, 253-265, 1987.
Kohno, T., Ishikawa, E.: A Novel Enzyme Immunoassay of Anti-Insulin IgG in Guinea Pig Serum. Biochem. Biophys. Res. Commun., 147, 644-649, 1987.
1986年
Ishikawa, E., Hashida, S., Kohno, T., Tanaka, K.: Enzyme Immunoassay. in “Clinical Biochemistry: Principle and Practice” (Gandasoebrata, R., Latu, J. and Hoyaranda, E. eds.), 1986, pp 81-87, The Organizing Committee of the 3rd Asian-Pacific Congress of Clinical Biochemistry (Djakarta, Indonesia).
Kohno, T., Ruan, K-h., Ishikawa, E.: A Highly Sensitive Enzyme Immunoassay of Anti-Insulin Antibodies in Guinea Pig Serum. Anal. Lett., 19, 1083-1095, 1986.
Kohno, T., Ishikawa, E.: A Highly Sensitive Enzyme Immunoassay of Anti-Insulin Antibodies in Guinea Pig Serum. J. Biochem., 100, 1247-1251, 1986.
Kohno, T., Yasuda, M., Murai, K., Hosomi, S., Mizoguchi, T.: Separation of the Molecular Forms of Chicken Liver Cytosolic Aldehyde Reductase and Comparison with Mitochondrial Aldehyde Reductase. Chem. Pharm. Bull., 34, 5034-5039, 1986.
1985年
Terada, T., Kohno, T., Samejima, T., Hosomi, S., Mizoguchi, T., Uehara, K.: Purification and Properties of Beef Liver Aldehyde Reductase Catalyzing the Reduction of D-Erythrose 4-Phosphate. J. Biochem., 97, 79-87, 1985.
Kohno, T., Hashida, S., Ishikawa, E.: A More Sensitive Enzyme Immunoassay of Anti-Insulin IgG in Guinea Pig Serum with Less Non-Specific Binding of Normal Guinea Pig IgG. J. Biochem., 98, 379-384, 1985.
Inoue, S., Hashida, S., Kohno, T., Tanaka, K., Ishikawa, E.: A Micro-Scale Method for the Conjugation of Affinity-Purified Fab' to β-D-Galactosidase from Escherichia Coli. J. Biochem., 98, 1387-1394, 1985.
1984年
Kohno, T., Hosomi, S., Mizoguchi, T.: Partial Purification and Some Properties of Mitochondrial Aldehyde Reductases from Chicken Liver. Chem. Pharm. Bull., 32, 3118-3127, 1984.
Kohno, T., Yasuda, M., Murai, K., Hosomi, S., Mizoguchi, T.: Aldehyde Reductases from Mitochondrial Fraction of Chicken Liver. J. Pharm. Dyn., 7, s-87, 1984.
Ohashi, K., Terada, T., Kohno, T., Hosomi, S., Mizoguchi, T., Uehara, K.: Enzymatic Isomerization and Epimerization of D-Erythrose 4-Phosphate and Its Quantitative Analysis by Gas Chromatography / Mass Spectrometry. Eur. J. Biochem., 142, 347-353, 1984.
紀要
板倉勲子，安原智久，辻琢巳，阪上由美，山本裕子，森谷利香，山本智津子，村松十和，奥野智史，木村朋紀，中尾晃幸，河野武幸，後閑容子，荻田喜代一：看護学部̶薬学部専門職連携教育の取り組みについて．摂南大学看護学研究，2(1): 57-67, 2014.
森谷利香，鎌田佳奈美，辻琢己，岩﨑綾乃，眞島崇：看護学部生・薬学部生による多職種連携教育の一環としての「患者安全」に関する実践報告 −協同授業を通した看護学生のイメージ変化−．摂南大学看護学研究，7(1): 20-27, 2019.
亀田直子，鎌田佳奈美，池田友美，菊田真穂，山本十三代，辻琢己：小児病棟での統合看護学実習における薬学部生との専門職連携教育の実践報告．摂南大学看護学研究，7(1): 12-19, 2019.