2025

How the Magenstrasse Is Formed After Meals: Protein Aggregation Hypothesis
Ryosuke Sakai, Yoshiyuki Shirasaka, Taiyo Takagi, Takato Masada, Keiko Minami, Makoto Kataoka, Ikumi Tamai, Toshihide Takagi, Shinji Yamashita
Journal of Pharmaceutical Sciences 114(2), 1351-1358, 2025

2024

In vitro demonstration of antedrug mechanism of a pharmacokinetic booster to improve CYP3A4 substrates by CYP-mediated metabolism inhibition
Makoto Kataoka, Sae Takenaka, Shota Fujii, Takato Masada, Keiko Minami, Toshihide Takagi, Masaaki Omote, Kentaro Kawai, Shinji Yamashita
Drug Metabolism and Pharmacokinetics 56, 101005, 2024

2023

Development of an In Vitro Methodology to Assess the Bioequivalence of Orally Disintegrating Tablets Taken without Water
Toshihide Takagi, Takato Masada, Keiko Minami, Makoto Kataoka, Shinji Yamashita
Pharmaceutics 15, 2192, 2023

Control of Dissolution and Supersaturation/Precipitation of Poorly Water-Soluble Drugs from Cocrystals Based on Solubility Products: A Case Study with a Ketoconaole Cocrystal
Makoto Kataoka, Ayaka Yonehara, Keiko Minami, Toshihide Takagi, Shinji Yamashita
Molecular Pharmaceutics 20(8), 4100-4107, 2023

The effects of degree and duration of supersaturation on in vivo absorption profiles for highly permeable drugs, dipyridamole and ketoconazole
Haruki Higashino, Keiko Minami, Toshihide Takagi, Makoto Kataoka, Shinji Yamashita
European Journal of Pharmaceutics and Biopharmaceutics 189, 48-55, 2023

Contribution analysis of metabolic tissues on systemic exposure of an active metabolite after oral administration of verapamil using a stable isotope-labeled compound
Makoto Kataoka, Shota Ohshiro, Keiko Minami, Tsubasa Hasegawa, Haruki Higashino, Toshihide Takagi, Kazutaka Togashi, Kuninori Mutaguchi, Shinji Yamashita
Drug Metabolism and Pharmacokinetics 51, 100514, 2023

ペプチドの経粘膜デリバリーを目的とした新規舌下適用型製剤の開発
南景子, 片岡誠, 高木敏英, 新居輝樹, 田畑泰彦, 山下伸二
Yakugaku Zasshi 143, 345-348, 2023

2022

Effects of ingested water volume on oral absorption of fenofibrate, a BCS class II drug, from micronized and amorphous solid dispersion formulations in rats
Makoto Kataoka, Sakiho Ikkou, Yuki Kato, Keiko Minami, Haruki Higashino, Toshihide Takagi, Shinji Yamashita
Biological and Pharmaceutical Bulletin 45, 1452-1457, 2022

Mechanistic analysis for positive and negative food effects on oral absorption of poorly soluble drugs from cyclodextrin containing formulations: Study with a mini-scale in vitro system
Risa Aihara, Keiko Minami, Roman Messerschmid, Koichi Wada, Toshihide Takagi, Shinji Yamashita
Journal of Drug Delivery Science and Technology 73, 103440, 2022

Liposomal Formulation for Oral Delivery of Cyclosporine A: Usefulness as a Semisolid-Dispersion System
Keiko Minami, Makoto Kataoka, Toshihide Takagi, Tomohiro Asai, Naoto Oku, Shinji Yamashita
Pharmaceutical Research 39, 977-987, 2022

Importance of Gastric Secretion and the Rapid Gastric Emptying of Ingested Water along the Lesser Curvature (“Magenstraße”) in Predicting the In Vivo Performance of Liquid Oral Dosage Forms in the Fed State Using a Modeling and Simulation
Tsuyoshi Kiyota, Atsushi Kambayashi, Toshihide Takagi, Shinji Yamashita
Molecular Pharmaceutics 19(2), 642-653, 2022

2021

In Vitro-In Vivo Correlation in Cocrystal Dissolution: Consideration of Drug Release Profiles Based on Coformer Dissolution and Absorption Behavior
Makoto Kataoka, Keiko Minami, Toshihide Takagi, Gregory E Amidon, Shinji Yamashita
Molecular Pharmaceutics 18(11), 4122-4130, 2021

Bioequivalence of Oral Drug Products in the Healthy and Special Populations: Assessment and Prediction Using a Newly Developed In Vitro System “BE Checker”
Takato Masada, Toshihide Takagi, Keiko Minami, Makoto Kataoka, Ken-ichi Izutsu, Kazuki Matsui, Shinji Yamashita
Pharmaceutics 13, 1136, 2021

New biphasic system in side-by-side chambers for testing drug dissolution and permeation in vitro (BiDP system)
Takato Masada, Toshihide Takagi, Keiko Minami, Makoto Kataoka, Shoko Takeyama, Yoshimine Fujii, Masayuki Takahashi, Shinji Yamashita
Journal of Drug Delivery Science and Technology 102747, 2021

In vitro-in vivo correlation in the effect of cyclodextrin on oral absorption of poorly soluble drugs
Risa Aihara, Roman Messerschmid, Masashi Mizoguchi, Koichi Wada, Keiko Minami, Haruki Higashino, Toshihide Takagi, Makoto Kataoka, Shinji Yamashita
International Journal of Pharmaceutics 600, 120494, 2021

In vitro sensitivity analysis of gastrointestinal dissolution profile of weakly basic drugs in the Stomach-to-Intestine Fluid Changing system: explanation for variable plasma exposure after oral administration
Toshihide Takagi, Takato Masada, Keiko Minami, Ken-ichi Izutsu, Kazuki Matsui and Shinji Yamashita
Molecular Pharmaceutics 18(4), 1711-1719, 2021