In vitro-in silico framework for evaluating intra-subject variability in the oral absorption of BCS class 1 drugs mediated by the gastric interdigestive migrating motor complex
International Journal of Pharmaceutics, 703, 127312, 2026
View Paper ↗2026
3 publicationsPredicting plasma concentration-time profiles of orally disintegrating tablets with delayed absorption under fed conditions without water
International Journal of Pharmaceutics, 698, 126931, 2026
View Paper ↗Mitigation of dose-dependent cilostazol absorption from cocrystals: A coformer regulates gastric dissolution and absorption profiles
Journal of Pharmaceutical Sciences, 115(4), 104191, 2026
View Paper ↗2025
3 publicationsInsights into In Vivo Performance of Amorphous Solid Dispersions: Evaluation Using a Surrogate Marker for Drug Release Profiles and Pharmacokinetic Analysis
Molecular Pharmaceutics, 22(12), 7455–7464, 2025
View Paper ↗Integrating In Vitro BE Checker with In Silico Physiologically Based Biopharmaceutics Modeling to Predict the Pharmacokinetic Profiles of Oral Drug Products
Pharmaceutics, 17(9), 1222, 2025
View Paper ↗How the Magenstrasse Is Formed After Meals: Protein Aggregation Hypothesis
Journal of Pharmaceutical Sciences, 114(2), 1351–1358, 2025
View Paper ↗2024
1 publicationIn vitro demonstration of antedrug mechanism of a pharmacokinetic booster to improve CYP3A4 substrates by CYP-mediated metabolism inhibition
Drug Metabolism and Pharmacokinetics, 56, 101005, 2024
View Paper ↗2023
5 publicationsDevelopment of an In Vitro Methodology to Assess the Bioequivalence of Orally Disintegrating Tablets Taken without Water
Pharmaceutics, 15, 2192, 2023
View Paper ↗Control of Dissolution and Supersaturation/Precipitation of Poorly Water-Soluble Drugs from Cocrystals Based on Solubility Products: A Case Study with a Ketoconaole Cocrystal
Molecular Pharmaceutics, 20(8), 4100–4107, 2023
View Paper ↗The effects of degree and duration of supersaturation on in vivo absorption profiles for highly permeable drugs, dipyridamole and ketoconazole
European Journal of Pharmaceutics and Biopharmaceutics, 189, 48–55, 2023
View Paper ↗Contribution analysis of metabolic tissues on systemic exposure of an active metabolite after oral administration of verapamil using a stable isotope-labeled compound
Drug Metabolism and Pharmacokinetics, 51, 100514, 2023
View Paper ↗ペプチドの経粘膜デリバリーを目的とした新規舌下適用型製剤の開発 (in Japanese)
薬学雑誌, 143, 345–348, 2023
View Paper ↗2022
4 publicationsEffects of ingested water volume on oral absorption of fenofibrate, a BCS class II drug, from micronized and amorphous solid dispersion formulations in rats
Biological and Pharmaceutical Bulletin, 45, 1452–1457, 2022
View Paper ↗Mechanistic analysis for positive and negative food effects on oral absorption of poorly soluble drugs from cyclodextrin containing formulations: Study with a mini-scale in vitro system
Journal of Drug Delivery Science and Technology, 73, 103440, 2022
View Paper ↗Liposomal Formulation for Oral Delivery of Cyclosporine A: Usefulness as a Semisolid-Dispersion System
Pharmaceutical Research, 39, 977–987, 2022
View Paper ↗Importance of Gastric Secretion and the Rapid Gastric Emptying of Ingested Water along the Lesser Curvature (“Magenstraße”) in Predicting the In Vivo Performance of Liquid Oral Dosage Forms in the Fed State Using a Modeling and Simulation
Molecular Pharmaceutics, 19(2), 642–653, 2022
View Paper ↗2021
5 publicationsIn Vitro-In Vivo Correlation in Cocrystal Dissolution: Consideration of Drug Release Profiles Based on Coformer Dissolution and Absorption Behavior
Molecular Pharmaceutics, 18(11), 4122–4130, 2021
View Paper ↗Bioequivalence of Oral Drug Products in the Healthy and Special Populations: Assessment and Prediction Using a Newly Developed In Vitro System “BE Checker”
Pharmaceutics, 13, 1136, 2021
View Paper ↗New biphasic system in side-by-side chambers for testing drug dissolution and permeation in vitro (BiDP system)
Journal of Drug Delivery Science and Technology, 102747, 2021
View Paper ↗In vitro-in vivo correlation in the effect of cyclodextrin on oral absorption of poorly soluble drugs
International Journal of Pharmaceutics, 600, 120494, 2021
View Paper ↗In vitro sensitivity analysis of gastrointestinal dissolution profile of weakly basic drugs in the Stomach-to-Intestine Fluid Changing system: explanation for variable plasma exposure after oral administration
Molecular Pharmaceutics, 18(4), 1711–1719, 2021
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