SETSUNAN UNIVERSITY · FACULTY OF PHARMACEUTICAL SCIENCES日本語 / English
PKSetsunan University
Laboratory of Pharmacokinetics and Clinical PharmaceuticsLABORATORY OF PHARMACOKINETICS AND CLINICAL PHARMACEUTICS
FROM FORMULATION TO HUMAN PHARMACOKINETICS

Understanding Drug Absorption.
Advancing Pharmaceutics.

Connecting drug dissolution from oral formulations and gastrointestinal absorption behavior to human pharmacokinetics.

Explore Our Research →Discover Lab Life →
IN VITRO × IN SILICO
DissolutionPermeationFood EffectsPK Prediction
NEWS & UPDATES

TOPICS

Research, awards, and laboratory updates

MediaOur research was featured in Setsunan University’s “Research Excellence” series. ↗
PublicationA collaborative paper with Taiho Pharmaceutical and Ritsumeikan University was published in the International Journal of Pharmaceutics. ↗
Press ReleaseSetsunan University issued a press release on a paper led by Yui Oyabu. ↗
PublicationA collaborative paper with Kyoto University and Ritsumeikan University was published in the International Journal of Pharmaceutics. ↗
Lab UpdateThe laboratory member list was updated. ↗
PublicationA paper on controlling the oral absorption of poorly water-soluble drugs using cocrystals was published in the Journal of Pharmaceutical Sciences. ↗
PublicationA collaborative paper with Daiichi Sankyo RD Novare, Sozai Research Tech, and Ritsumeikan University was published in Molecular Pharmaceutics. ↗
PublicationA collaborative paper with Tokyo University of Science, NIHS, and Ritsumeikan University was published in Pharmaceutics. ↗
OUR RESEARCH

Our Research

We connect drug dissolution from dosage forms and gastrointestinal absorption processes to human pharmacokinetics, supporting the development of better medicines.

BE Checker apparatus used to evaluate bioequivalence01

Predicting Bioequivalence

Using in vitro tools such as the BE Checker to assess differences in drug absorption between formulations.

Fasted (blue) and fed (orange) plasma concentration profiles02

Food Effects on Drug Absorption

Investigating how changes in gastrointestinal conditions after meals affect oral drug absorption.

Illustration of a small amount of water passing through the pylorus03

Evaluation of Drug Emptying from the Stomach

Developing experimental approaches to characterize the gastric behavior and emptying of drugs and formulations.

Circular IMMC diagram showing Phase I through IV04

Variability in Drug Absorption

Exploring how physiological differences in the gastrointestinal tract contribute to variability in oral absorption.

Computer and gears illustrating pharmacokinetic modeling05

Pharmacokinetic Modeling

Integrating experimental results and mathematical models to predict plasma concentration–time profiles.

SELECTED PUBLICATIONS

Selected Publications

A selection of our published research.

2026
Predicting plasma concentration-time profiles of orally disintegrating tablets with delayed absorption under fed conditions without waterY. Oyabu et al. · International Journal of Pharmaceutics, 698, 126931
論文を見る ↗
2025
How the Magenstrasse Is Formed After Meals: Protein Aggregation HypothesisR. Sakai et al. · Journal of Pharmaceutical Sciences, 114(2), 1351–1358
論文を見る ↗
2023
Development of an In Vitro Methodology to Assess the Bioequivalence of Orally Disintegrating Tablets Taken without WaterT. Takagi et al. · Pharmaceutics, 15(9), 2192
論文を見る ↗
View All Publications ↗
LAB LIFE

Research, Collaboration,
and Life in Our Lab.

Our laboratory brings students and faculty together through experiments, data analysis, and lively scientific discussions. Beyond research, we value opportunities to connect, exchange ideas, and grow through shared experiences.

Faculty & Members ↗

Laboratory members during a group outing