研究業績
八木晴也(助教)
原著論文
- Yusuke Tanaka, Rikuto Fukaishi, Daiki Okamoto, Takanori Kurakazu, Tokio Nakai, Haruya Yagi, Shinji Sakuma. Impact of Composition of Lipid-Based Formulations on First-Pass Drug Metabolism after Oral Administration, Mol. Pharmaceutics, in press.
- Haruya Yagi, Takumi Tomono, Koji Abe, Yasuhiro Tsutsumi, Muneyoshi Makabe, Hiromi Mitsuhashi, Takayuki Kimura, Hideo Kobayashi, Kohei Miyata, Koichi Shigeno, Shinji Sakuma, Validation of the absorption-enhancing ability of oligoarginines grafted onto a backbone of hyaluronic acid through animal studies from rodents to primates, Mol. Pharmaceutics.,21 (2024) 3485-3501.
- Yusuke Tanaka, Hinata Arai, Aya Hidaka, Saki Noda, Ko Imai, Fumiya Tsujisawa, Haruya Yagi, Shinji Sakuma, In Vitro Digestion–In Situ Absorption Setup Employing a Physiologically Relevant Value of the Membrane Surface Area/Volume Ratio for Evaluating Performance of Lipid-Based Formulations: A Comparative Study with an In Vitro Digestion–Permeation Model, Mol. Pharmaceutics., 21 (2024) 3459-3470.
- Yuri Fujioka, Hideto Ueki, Ruhan, Akari Sasajima, Takumi Tomono, Masami Ukawa, Haruya Yagi, Shinji Sakuma, Koichi Kitagawa, Toshiro Shirakawa, The Improved Antigen Uptake and Presentation of Dendritic Cells Using Cell-Penetrating D-octaarginine-Linked PNVA-co-AA as a Novel Dendritic Cell-Based Vaccine, Int. J. Mol. Sci. 25 (2024) 5997.
- Takumi Tomono, Haruya Yagi, Ryoji Igi, Akihiro Tabaru, Koichi Fujimoto, Kaho Enomoto, Masami Ukawa, Kohei Miyata, Koichi Shigeno, Shinji Sakuma, Mucosal absorption of antibody drugs enhanced by cell-penetrating peptides anchored to a platform of polysaccharides, Int. J. Pharm., 647 (2023) 123499.
- Haruya Yagi, Takumi Tomono, Yuma Handa, Natsuki Saito, Masami Ukawa, Kohei Miyata, Koichi Shigeno, Shinji Sakuma,Performance of cell-penetrating peptides anchored to polysaccharide platforms applied via various mucosal routes as an absorption enhancer, Mol. Pharmaceutics., 20 (2023) 303-313.
- Takumi Tomono, Haruya Yagi, Saki Kanemoto, Masami Ukawa, Kohei Miyata, Koichi Shigeno, Shinji Sakuma, Acquisition of absorption-enhancing abilities of cationic oligopeptides with short chain arginine residues through conjugation to hyaluronic acid, Int. J. Pharm., 616 (2022) 121519.
- Masami Ukawa, Rikito Endo, Haruya Yagi, Takumi Tomono, Kohei Miyata, Koichi Shigeno, Etsuo Tobita, Tomofumi Uto, Masanori Baba, Shinji Sakuma, Mechanism on antigen delivery under mucosal vaccination using cell-penetrating peptides immobilized at multiple points on polymeric platforms, Int. J. Pharm., 613 (2022) 121376.
- Takumi Tomono, Haruya Yagi, Masami Ukawa, Seiya Ishizaki, Takahiro Miwa, Mao Nonomura, Ryoji Igi, Hironori Kumagai, Kohei Miyata, Etsuo Tobita, Hideo Kobayashi, Shinji Sakuma, Nasal absorption enhancement of protein drugs independent to their chemical properties in the presence of hyaluronic acid modified with tetraglycine-L-octaarginine, Eur. J. Pharm. Biopharm., 154 (2020) 186-194.
- Masami Ukawa, Sohei Tanishita, Haruya Yagi, Yuki Yoshida, Takumi Tomono, Koichi Shigeno, Etsuo Tobita, Tomofumi Uto, Masanori Baba, Shinji Sakuma, Biodegradable hyaluronic acid modified with tetraglycine-L-octaarginine as a safe adjuvant for mucosal vaccination, Mol. Pharmaceutics., 16 (2019) 1105-1118.
- Kohta Mohri, Kohei Miyata, Tomomi Egawa, Sohei Tanishita, Rikito Endo, Haruya Yagi, Masami Ukawa, Kyohei Ochiai, Ken-ichiro Hiwatari, Kazufumi Tsubaki, Koichi Shigeno, Etsuo Tobita, Tomofumi Uto, Masanori Baba, Shinji Sakuma, Effects of the chemical structures of oligoarginines conjugated to biocompatible polymers as a mucosal adjuvant on antibody induction in nasal cavities. Chem Pharm Bull., 66 (4) (2018) 375-381.
総説・解説
- 八木晴也,佐久間信至,“バイオ医薬の経粘膜吸収促進を可能にする膜透過ペプチド固定化高分子の開発”「月刊「細胞」2023年8月号 中分子ペプチドが拓く明日の創薬」(2023年7月22日)pp.27-32