1. Yusuke Tanaka, Rikuto Fukaishi, Daiki Okamoto, Takanori Kurakazu, Tokio Nakai, Haruya Yagi, Shinji Sakuma. Impact of Composition of Lipid-Based Formulations on First-Pass Drug Metabolism after Oral Administration, Mol. Pharmaceutics, in press.
2. Haruya Yagi, Takumi Tomono, Koji Abe, Yasuhiro Tsutsumi, Muneyoshi Makabe, Hiromi Mitsuhashi, Takayuki Kimura, Hideo Kobayashi, Kohei Miyata, Koichi Shigeno, Shinji Sakuma, Validation of the absorption-enhancing ability of oligoarginines grafted onto a backbone of hyaluronic acid through animal studies from rodents to primates, Mol. Pharmaceutics.,21 (2024) 3485-3501.
3. Yusuke Tanaka, Hinata Arai, Aya Hidaka, Saki Noda, Ko Imai, Fumiya Tsujisawa, Haruya Yagi, Shinji Sakuma, In Vitro Digestion–In Situ Absorption Setup Employing a Physiologically Relevant Value of the Membrane Surface Area/Volume Ratio for Evaluating Performance of Lipid-Based Formulations: A Comparative Study with an In Vitro Digestion–Permeation Model, Mol. Pharmaceutics.,21 (2024) 3459-3470.
4. Yuri Fujioka, Hideto Ueki, Ruhan, Akari Sasajima, Takumi Tomono, Masami Ukawa, Haruya Yagi, Shinji Sakuma, Koichi Kitagawa, Toshiro Shirakawa, The Improved Antigen Uptake and Presentation of Dendritic Cells Using Cell-Penetrating D-octaarginine-Linked PNVA-co-AA as a Novel Dendritic Cell-Based Vaccine, Int. J. Mol. Sci. 25 (2024) 5997.
5. Takumi Tomono, Haruya Yagi, Ryoji Igi, Akihiro Tabaru, Koichi Fujimoto, Kaho Enomoto, Masami Ukawa, Kohei Miyata, Koichi Shigeno, Shinji Sakuma, Mucosal absorption of antibody drugs enhanced by cell-penetrating peptides anchored to a platform of polysaccharides, Int. J. Pharm., 647 (2023) 123499.
6. Haruya Yagi, Takumi Tomono, Yuma Handa, Natsuki Saito, Masami Ukawa, Kohei Miyata, Koichi Shigeno, Shinji Sakuma,Performance of cell-penetrating peptides anchored to polysaccharide platforms applied via various mucosal routes as an absorption enhancer, Mol. Pharmaceutics., 20 (2023) 303-313.
7. Saki Sakuma, Mariko Okamoto, Nao Matsushita, Masami Ukawa, Takumi Tomono, Keiko Kawamoto, Teruo Ikeda, Shinji Sakuma, Evaluation of a D-Octaarginine-linked polymer as a transfection tool for transient and stable transgene expression in human and murine cell lines. J. Vet. Med. Sci. 84 (2022) 484-493.
8. Takumi Tomono, Haruya Yagi, Saki Kanemoto, Masami Ukawa, Kohei Miyata, Koichi Shigeno, Shinji Sakuma, Acquisition of absorption-enhancing abilities of cationic oligopeptides with short chain arginine residues through conjugation to hyaluronic acid, Int. J. Pharm., 616 (2022) 121519.
9. Masami Ukawa, Rikito Endo, Haruya Yagi, Takumi Tomono, Kohei Miyata, Koichi Shigeno, Etsuo Tobita, Tomofumi Uto, Masanori Baba, Shinji Sakuma, Mechanism on antigen delivery under mucosal vaccination using cell-penetrating peptides immobilized at multiple points on polymeric platforms, Int. J. Pharm., 613 (2022) 121376.
10. Kohta Mohri, Emi Hayashi, Manato Nishino, Nao Matsushita, Sohei Tanishita, Makiya Nishikawa, Shinji Sakuma, Polypod-like structured guanine-rich oligonucleotide aptamer as a selective and cytotoxic nanostructured DNA to cancer cells, J. Drug. Target.,29 (2021) 217-224.
11. Takumi Tomono, Haruya Yagi, Masami Ukawa, Seiya Ishizaki, Takahiro Miwa, Mao Nonomura, Ryoji Igi, Hironori Kumagai, Kohei Miyata, Etsuo Tobita, Hideo Kobayashi, Shinji Sakuma, Nasal absorption enhancement of protein drugs independent to their chemical properties in the presence of hyaluronic acid modified with tetraglycine-L-octaarginine, Eur. J. Pharm. Biopharm., 154 (2020) 186-194.
12. Sohei Tanishita, Masami Ukawa, Takumi Tomono, Yuki Yoshida, Takumi Tsujioka, Kohei Miyata, Etsuo Tobita, Tomofumi Uto, Masanori Baba, Shinji Sakuma, Cross-protective Abilities of Hyaluronic Acid Modified with Tetraglycine-L-octaarginine as a Mucosal Adjuvant against Infection with Heterologous Influenza Viruses, Bioconjug. Chem., 30 (2019) 3028-3037.
13. Masami Ukawa, Sohei Tanishita, Haruya Yagi, Yuki Yoshida, Takumi Tomono, Koichi Shigeno, Etsuo Tobita, Tomofumi Uto, Masanori Baba, Shinji Sakuma, Biodegradable hyaluronic acid modified with tetraglycine-L-octaarginine as a safe adjuvant for mucosal vaccination, Mol. Pharmaceutics., 16 (2019) 1105-1118.
14. Hironori Kumagai, Kosuke Yamada, Kanako Nakai, Tokio Kitamura, Kohta Mohri, Masami Ukawa, Takumi Tomono, Takaaki Eguchi, Tetsuya Yoshizaki, Takumi Fukuchi, Takuya Yoshino, Minoru Matsuura, Etsuo Tobita, Wellington Pham, Hiroshi Nakase, Shinji Sakuma, Tumor recognition of peanut agglutinin-immobilized fluorescent nanospheres in biopsied human tissues, Eur. J. Pharm. Biopharm., 136 (2019) 29-37.
15. Shawn Barton, Bo Li, Michael Siuta, Vaibhav A Janve, Jessica Song, Clinton M. Holt, Takumi Tomono, Masami Ukawa, Hironori Kumagai, Etsuo Tobita, Kevin Wilson, Shinji Sakuma, Wellington Pham, Specific molecular recognition as a strategy to delineate tumor margin using topically applied fluorescence embedded nanoparticles, Prec. Nanomed., 1 (3) (2018) 194-207.
16. Kohsaku Kawakami, Keiko Sato, Mayuko Fukushima, Aoi Miyazaki, Yuko Yamamura, Shinji Sakuma, Phase separation of supersaturated solution created from amorphous solid dispersions: Relevance to oral absorption, Eur. J. Pharm. Biopharm., 132 (2018) 146-156.
17. Kohei Miyata, Masami Ukawa, Kohta Mohri, Kozue Fujii, Mako Yamada, Sohei Tanishita, Satoshi Higashitarumi, Seiya Ishizaki, Hironori Kumagai, Kyohei Ochiai, Ken-ichiro Hiwatari, Kazufumi Tsubaki, Koichi Shigeno, Etsuo Tobita, Hideo Kobayashi, Shinji Sakuma, Biocompatible polymers modified with D-octaarginine as an absorption enhancer for nasal peptide delivery. Bioconjug. Chem., 29 (2018) 1748-1755.
18. Kohta Mohri, Kohei Miyata, Tomomi Egawa, Sohei Tanishita, Rikito Endo, Haruya Yagi, Masami Ukawa, Kyohei Ochiai, Ken-ichiro Hiwatari, Kazufumi Tsubaki, Koichi Shigeno, Etsuo Tobita, Tomofumi Uto, Masanori Baba, Shinji Sakuma, Effects of the chemical structures of oligoarginines conjugated to biocompatible polymers as a mucosal adjuvant on antibody induction in nasal cavities. Chem.Pharm. Bull., 66 (4) (2018) 375-381.
19. Kohta Mohri, Kengo Nagata, Shozo Ohtsuki, Shiori Toyama, Mao Nonomura, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa, Shinji Sakuma, Elucidation of the mechanism of increased activity of immunostimulatory DNA by the formation of polypod-like structure. Pharm Res., 34 (11) (2017) 2362-2370.
20. Hiroshi Nakase, Shinji Sakuma, Takumi Fukuchi, Takuya Yoshino, Kohta Mohri, Kohei Miyata, Hironori Kumagai, Ken-Ichiro Hiwatari, Kazufumi Tsubaki, Tetsuya Ikejima, Etsuo Tobita, Meiying Zhu, Kelvin Wilson, Kay Washington, John C Gore, Wellington Pham, Evaluation of a novel fluorescent nanobeacon for targeted imaging of Thomsen-Friedenreich associated colorectal cancer. Int. J. Nanomedicine, 12 (2017) 1747-1755.
21. Kohsaku Kawakami, Aoi Miyazaki, Mayuko Fukushima, Keiko Sato, Yuko Yamamura, Kohta Mohri, Shinji Sakuma, Physicochemical properties of solid phospholipid particles as a drug delivery platform for improving oral absorption of poorly soluble drugs. Pharm. Res., 34 (1) (2017) 208-216.
22. Makoto Kataoka, Chie Kojima, Kazuki Ueda, Keiko Minami, Haruki Higashino, Shinji Sakuma, Kazutaka Togashi, Kuninori Mutaguchi, Shinji Yamashita, Quantitative analysis of pharmacokinetic profiles of verapamil and drug-drug interactions induced by a CYP inhibitor using a stable isotope-labeled compound. Drug Metab. Pharmacokinet., 31 (6) (2016) 405-410.
23. Kohei Miyata, Kohta Mohri, Tomomi Egawa, Rikito Endo, Naoki Morimoto, Kyohei Ochiai, Ken-ichiro Hiwatari, Kazufumi Tsubaki, Etsuo Tobita, Tomofumi Uto, Masanori Baba, Shinji Sakuma, Demonstration of D-octaarginine-linked polymers as promising adjuvants for mucosal vaccination through influenza virus challenge. Bioconjug. Chem. 27 (2016) 1865-1871.
24. Makoto Kataoka, Miho Fukahori, Atsumi Ikemura, Ayaka Kubota, Haruki Higashino, Shinji Sakuma, Shinji Yamashita, Effects of gastric pH on oral drug absorption: In vitro assessment using a dissolution/permeation system reflecting the gastric dissolution process. Eur. J. Pharm. Biopharm., 101(2016)103-111.
25. Koji Yano, Makoto Kataoka, Shizuka Ono, Makoto Hiramatsu, Ichiro Matsumoto, Soon Ih Kim, Haruki Higashino, Shinji Sakuma, Shinji Yamashita, Evaluation of dose-dependent oral absorption of a newly developed drug candidate: in vitro-in vivo correlation. J. Drug Deliv. Sci. Technol., 31(2016)160-166.
26. Kohta Mohri, Naoki Morimoto, Megumi Maruyama, Norimasa Nakamoto, Emi Hayashi, Kengo Nagata, Kohei Miyata, Kyohei Ochiai, Ken-ichiro Hiwatari, Kazufumi Tsubaki, Etsuo Tobita, Yuki Ishimaru, Sadaaki Maeda, Shinji Sakuma, Potential of D-octaarginine-linked polymers as an in vitro transfection tool of biomolecules. Bioconjug. Chem., 26 (2015) 1782-1790.
27. Shinji Sakuma, Satoshi Matsumoto, Narimoto Ishizuka, Kohta Mohri, Mayuko Fukushima, Chie Ohba, Kohsaku Kawakami, Enhanced boosting of oral absorption of lopinavir through electrospray co-encapsulation with ritonavir. J. Pharm. Sci. 104 (9) (2015) 2977-2985.
28. Yusuke Tanaka, Takanori Goto, Makoto Kataoka, Shinji Sakuma, Shinji Yamashita, Impact of luminal fluid volume on the drug absorption after oral administration: analysis based on in vivo drug concentration-time profile in the gastrointestinal tract. J. Pharm. Sci. 104 (9) (2015) 3120-3127.
29. Shinji Sakuma, Hironori Kumagai, Moe Shimosato, Tokio Kitamura, Kohta Mohri, Tetsuya Ikejima, Ken-ichiro Hiwatari, Seiji Koike, Etsuo Tobita, Richard McClure, John C. Gore, Wellington Pham, Toxicity studies of coumarin 6-encapsulated polystyrene nanospheres conjugated with peanut agglutinin and poly(N-vinylacetamide) as a colonoscopic imaging agent in rats, Nanomedicine: NBM, 11(5)(2015) 1227-1236.
30. Shinji Sakuma, Naoki Morimoto, Kazuhiro Nishida, Tomofumi Murakami, Tomomi Egawa, Rikito Endo, Makoto Kataoka, Shinji Yamashita, Kohei Miyata, Kohta Mohri, Kyohei Ochiai, Ken-ichiro Hiwatari, Seiji Koike, Etsuo Tobita, Tomofumi Uto, Masanori Baba, Cross-reactivity of immunoglobulin A secreted on the nasal mucosa in mice nasally inoculated with inactivated H1N1 influenza A viruses in the presence of D-octaarginine-linked polymers, Eur. J. Pharm. Biopharm. 92 (2015) 56-64.
31. Tokio Kitamura, Shinji Sakuma, Moe Shimosato, Haruki Higashino, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Ken-ichiro Hiwatari, Hironori Kumagai, Naoki Morimoto, Seiji Koike, Etsuo Tobita, Robert M. Hoffman, John C. Gore, Wellington Pham, Specificity of lectin-immobilized fluorescent nanospheres for colorectal tumors in a mouse model which better resembles the clinical disease. Contrast Media Mol. Imaging, 10 (2015) 135-143.
32. Shinji Sakuma, James Y. H. Yu, Timothy Quang, Ken-ichiro Hiwatari, Hironori Kumagai, Stephanie Kao, Alex Holt, Jalysa Erskind, Richard McClure, Michael Siuta, Tokio Kitamura, Etsuo Tobita, Seiji Koike, Kevin Wilson, Rebecca Richards-Kortum, Eric Liu, Kay Washington, Reed Omary, John C. Gore, Wellington Pham, Fluorescence-based endoscopic imaging of Thomsen-Friedenreich antigen to improve early detection of colorectal cancer, Int. J. Cancer 136 (5) (2015) 1095-1103.
33. Makoto Kataoka, Saki Tsuneishi, Yukako Maeda, Yoshie Masaoka, Shinji Sakuma, Shinji Yamashita, A new in vitro system for evaluation of passive intestinal drug absorption: establishment of a double artificial membrane permeation assay, Eur. J. Pharm. Biopharm. 88 (3) (2014) 840-846.
34. Haruki Higashino, Tsubasa Hasegawa, Mari Yamamoto, Rie Matsui, Yoshie Masaoka, Makoto Kataoka, Shinji Sakuma, Shinji Yamashita, In vitro-in vivo correlation in the effect of supersaturation on intestinal absorption of BCS class 2 drugs. Mol. Pharmaceutics 11 (3) (2014) 746-54.
35. Yoshimine Fujii, Masayuki Takahashi, Takako Ishiguro, Shinji Sakuma, Kaneto Uekama, Tetsumi Irie, Cyclodextrins improve oral absorption of a novel factor Xa inhibitor by interfering with interaction between the drug and bile acids in rats. J. Pharm. Pharmacol. 65 (11) (2013) 1598-1606.
36. Makoto Kataoka, Koji Yano, Yoriko Hamatsu, Yoshie Masaoka, Shinji Sakuma, Shinji Yamashita, Assessment of absorption potential of poorly water-soluble drugs by using the dissolution/permeation system. Eur. J. Pharm. Biopharm. 85 (3B) (2013) 1317–1324.
37. Kohsaku Kawakami, Shaoling Zhang, Rohit Singh Chauhan, Narimoto Ishizuka, Marina Yamamoto, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Shinji Sakuma, Preparation of fenofibrate solid dispersion using electrospray deposition and improvement in oral absorption by instantaneous post-heating of the formulation. Int. J. Pharm. 450 (1-2) (2013) 123-128.
38. Shinji Yamashita, Makoto Kataoka, Haruki Higashino, Shinji Sakuma, Takashi　Sakamoto, Hinako Uchimaru, Hiroshi Tsukikawa, Masanari Shiramoto, Hitoshi Uchiyama, Hidehisa Tachiki, Shin Irie, Measurement of drug concentration in the stomach after intragastric administration of drug solution to healthy volunteers: Analysis of intragastric fluid dynamics and drug absorption. Pharm. Res. 30 (4) (2013) 951-958.
39. Hironori Kumagai, Wellington Pham, Makoto Kataoka, Ken-ichiro Hiwatari, James McBride, Kevin Wilson, Hiroyuki Tachikawa, Ryoji Kimura, Kunio Nakamura, Eric Liu, John Gore, Shinji Sakuma, Multifunctional nanobeacon for imaging Thomsen-Friedenreich antigen-associated colorectal cancer. Int. J. Cancer 132 (9) (2013) 2107-2117.
40. Makoto Kataoka, Yuki Terashima, Katsuhiko Mizuno, Yoshie Masaoka, Shinji Sakuma, Tsuyoshi Yokoi, Shinji Yamashita, Establishment of MDCKII cell monolayer with metabolic activity by CYP3A4 transduced with recombinant adenovirus. Drug Metab. Pharmacokinet. 28 (2) (2013) 125-131.
41. Shinji Sakuma, Masaya Suita, Saki Inoue, Yoko Marui, Kazuhiro Nishida, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Noriko Nakajima, Norihiro Shinkai, Hitoshi Yamauchi, Ken-ichiro Hiwatari, Hiroyuki Tachikawa, Ryoji Kimura, Tomofumi Uto, Masanori Baba, Cell-penetrating peptide-linked polymers as carriers for mucosal vaccine delivery. Mol. Pharmaceutics 9 (10) (2012) 2933-2941.
42. Makoto Kataoka, Tadayuki Takashima, Tomotaka Shingaki, Yoshinobu Hashidzume, Yumiko Katayama, Yasuhiro Wada, Hiroyuki Oh, Yoshie Masaoka, Shinji Sakuma, Yuichi Sugiyama, Shinji Yamashita, Yasuyoshi Watanabe, Dynamic analysis of GI absorption and hepatic distribution processes of telmisartan in rats using positron emission tomography. Pharm. Res. 29 (9) (2012) 2419-2431.
43. Makoto Kataoka, Kiyohiko Sugano, Claudia da Costa Mathews, Cheryl Wong Jing Wen, Kelly Jones, Yoshie Masaoka, Shinji Sakuma, Shinji Yamashita, Application of dissolution/permeation system for evaluation of formulation effect on oral absorption of poorly water-soluble drugs in drug development. Pharm. Res. 29 (6) (2012) 1485-1494.
44. Shinji Sakuma, Masaya Suita, Takafumi Yamamoto, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Noriko Nakajima, Norihiro Shinkai, Hitoshi Yamauchi, Ken-ichiro Hiwatari, Akio Hashizume, Hiroyuki Tachikawa, Ryoji Kimura, Yuki Ishimaru, Atsushi Kasai, Sadaaki Maeda, Performance of cell-penetrating peptide-linked polymers physically mixed with poorly membrane-permeable molecules on cell membranes. Eur. J. Pharm. Biopharm. 81 (1) (2012) 64-73.
45. Shinji Sakuma, Shun Kanamitsu, Yumi Teraoka, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Yoshiyuki Shirasaka, Ikumi Tamai, Masahiro Muraoka, Yohji Nakatsuji, Toshiyuki Kida, Mitsuru Akashi, Involvement of functional groups on the surface of carboxyl group-terminated polyamidoamine dendrimers bearing arbutin in inhibition of Na+/glucose cotransporter 1 (SGLT1)-mediated D-glucose uptake. Mol. Pharmaceutics 9 (4) (2012) 922-929.
46. Yoshimine Fujii, Taro Kanamaru, Hiroshi Kikuchi, Hiroaki Nakagami, Shinji Yamashita, Mitsuru Akashi, Shinji Sakuma, Improvement of low bioavailability of a novel factor Xa inhibitor through formulation of cationic additives in its oral dosage form. Int. J. Pharm. 421 (2) (2011) 244-251.
47. Makoto Kataoka, Tomonori Yokoyama, Yoshie Masaoka, Shinji Sakuma, Shinji Yamashita, Estimation of P-glycoprotein-mediated efflux in oral absorption of P-gp substrate drugs from simultaneous analysis of drug dissolution and permeation. Eur. J. Pharm. Sci., 44 (4) (2011) 544-551.
48. Shinji Sakuma, Haruki Higashino, Hitomi Oshitani, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Ken-ichiro Hiwatari, Hiroyuki Tachikawa, Ryoji Kimura, Kunio Nakamura, Hironori Kumagai, John C. Gore, Wellington Pham, Essence of affinity and specificity of peanut agglutinin-immobilized fluorescent nanospheres with surface poly(N-vinylacetamide) chains for colorectal cancer. Eur. J. Pharm. Biopharm. 79 (3) (2011) 537-543.
49. Shinji Sakuma, Hidehisa Tachiki, Hitoshi Uchiyama, Yasunobu Fukui, Naohiro Takeuchi, Kazuo Kumamoto, Tomonori Satoh, Yoshinobu Yamamoto, Emi Ishii, Yoshiyuki Sakai, Susumu Takeuchi, Masaru Sugita, Shinji Yamashita, A perspective for biowaivers of human bioequivalence studies on the basis of the combination of the ratio of AUC to the dose and the biopharmaceutics classification system. Mol. Pharmaceutics 8 (4) (2011) 1113-1119.
50. Makoto Kataoka, Katsuaki Iwai, Yoshie Masaoka, Toshiyasu Sakane, Shinji Sakuma, Shinji Yamashita, Scale-up of in vitro permeation assay data to human intestinal permeability using pore theory. Int. J. Pharm. 414 (1-2) (2011) 69-76.
51. Shaoling Zhang, Kohsaku Kawakami, Marina Yamamoto, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Shinji Sakuma, Coaxial electrospray formulations for improving oral absorption of a poorly water-soluble drug. Mol. Pharmaceutics 8 (2011) 807-813.
52. Yoshimine Fujii, Taro Kanamaru, Hiroshi Kikuchi, Shinji Yamashita, Shinji Sakuma, Enteric-coated tablets improve oral bioavailability of DX-9065, a novel anticoagulant. Eur. J. Pharm. Sci. 42 (4) (2011) 392-399.
53. Shinji Sakuma, Makoto Kataoka, Haruki Higashino, Takanori Yano, Yoshie Masaoka, Shinji Yamashita, Ken-ichiro Hiwatari, Hiroyuki Tachikawa, Ryoji Kimura, Kunio Nakamura, Hironori Kumagai, John C. Gore, Wellington Pham, A potential of peanut agglutinin-immobilized fluorescent nanospheres as a safe candidate of diagnostic drugs for colonoscopy. Eur. J. Pharm. Sci. 42 (4) (2011) 340-347.
54. Makoto Kataoka, Sachi Itsubata, Yoshie Masaoka, Shinji Sakuma, Shinji Yamashita, In vitro dissolution/permeation system to predict the oral absorption of poorly water-soluble drugs: effect of food and dose strength on it. Biol. Pharm. Bull. 34 (3) (2011) 401-411.
55. Shinji Yamashita, Tadayuki Takashima, Makoto Kataoka, Hiroyuki Oh, Shinji Sakuma, Masayuki Takahashi, Norio Suzuki, Emi Hayashinaka, Yasuhiro Wada, Yilong Cui, Yasuyoshi Watanabe, Imaging of gastrointestinal absorption process of orally administered drugs using positron emission tomography. J. Nucl. Med. 52 (2) (2011) 249-256.
56. Shinji Sakuma, Masaya Suita, Yoshie Masaoka, Makoto Kataoka, Noriko Nakajima, Norihiro Shinkai, Hitoshi Yamauchi, Ken-ichiro Hiwatari, Hiroyuki Tachikawa, Ryoji Kimura, Shinji Yamashita, Oligoarginine-linked polymers as a new class of penetration enhancers. J. Control. Release 148 (2) (2010) 187-196.
57. Shinji Sakuma, Yumi Teraoka, Tomokazu Sagawa, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Yoshiyuki Shirasaka, Ikumi Tamai, Yusuke Ikumi, Toshiyuki Kida, Mitsuru Akashi, Carboxyl group-terminated polyamidoamine dendrimers bearing glucosides inhibit intestinal hexose transporter-mediated D-glucose uptake. Eur. J. Pharm. Biopharm. 75 (3) (2010) 366-374.
58. Shinji Sakuma, Takanori Yano, Yoshie Masaoka, Makoto Kataoka, Ken-ichiro Hiwatari, Hiroyuki Tachikawa, Yoshikazu Shoji, Ryoji Kimura, Huaiyu Ma, Zhijian Yang, Li Tang, Robert M. Hoffman, Shinji Yamashita, Detection of early colorectal cancer imaged with peanut agglutinin-immobilized fluorescent nanospheres having surface poly(N-vinylacetamide) chains. Eur. J. Pharm. Biopharm. 74 (3) (2010) 451-460.
59. Koji Yano, Yoshie Masaoka, Makoto Kataoka, Shinji Sakuma, Shinji Yamashita, Mechanisms of membrane transport of poorly soluble drugs: role of micelles in oral absorption processes. J. Pharm. Sci. 99 (3) (2010) 1336-1345.
60. Shinji Sakuma, Ryoko Ogura, Yoshie Masaoka, Makoto Kataoka, Fumie K. Tanno, Hiroyasu Kokubo, Shinji Yamashita, Correlation between in vitro dissolution profiles from enteric-coated dosage forms and in vivo absorption in rats for high-solubility and high-permeability model drugs. J. Pharm. Sci. 98 (11) (2009) 4141-4152.
61. Shinji Sakuma, Takanori Yano, Yoshie Masaoka, Makoto Kataoka, Ken-ichiro Hiwatari, Hiroyuki Tachikawa, Yoshikazu Shoji, Ryoji Kimura, Huaiyu Ma, Zhijian Yang, Li Tang, Robert M. Hoffman, Shinji Yamashita, In vitro/in vivo biorecognition of lectin-immobilized fluorescent nanospheres for human colorectal cancer cells. J. Control. Release 134 (1) (2009) 2-10.
62. Shinji Sakuma, Tomokazu Sagawa, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Yoshiyuki Shirasaka, Ikumi Tamai, Yusuke Ikumi, Toshiyuki Kida, Mitsuru Akashi, Stabilization of enzyme-susceptible glucoside bonds of phloridzin through conjugation with poly(γ-glutamic acid). J. Control. Release 133 (2) (2009) 125-131.
63. Fumie K. Tanno, Shinji Sakuma, Yoshie Masaoka, Makoto Kataoka, Toshio Kozaki, Ryosei Kamaguchi, Yutaka Ikeda, Hiroyasu Kokubo, Shinji Yamashita, Site-specific drug delivery to the middle-to-lower region of the small intestine reduces food-drug interactions that are responsible for low drug absorption in the fed state. J. Pharm. Sci. 97 (12) (2008) 5341-5353.
64. Ken-ichiro Hiwatari, Shinji Sakuma, Kiyoko Iwata, Yoshie Masaoka, Makoto Kataoka, Hiroyuki Tachikawa, Yoshikazu Shoji, Shinji Yamashita, Poly(N-vinylacetamide) chains enhance lectin-induced biorecognition through the reduction of nonspecific interactions with non-targets. Eur. J. Pharm. Biopharm. 70 (2) (2008) 453-461.
65. Fumie K. Tanno, Shinji Sakuma, Yoshie Masaoka, Makoto Kataoka, Toshio Kozaki, Ryosei Kamaguchi, Yutaka Ikeda, Hiroyasu Kokubo, Shinji Yamashita, Site-specific drug delivery to the middle region of the small intestine by application of enteric coating with hypromellose acetate succinate (HPMCAS). J. Pharm. Sci. 97 (7) (2008) 2665-2679.
66. Yoshiyuki Shirasaka, Yoshie Masaoka, Makoto Kataoka, Shinji Sakuma, Shinji Yamashita, Scaling of in vitro membrane permeability to predict P-glycoprotein-mediated drug absorption in vivo. Drug Metab. Dispo. 36 (5) (2008) 916-922.
67. Yusuke Ikumi, Toshiyuki Kida, Shinji Sakuma, Shinji Yamashita, Mitsuru Akashi, Polymer-phloridzin conjugates as an anti-diabetic drug that inhibits glucose absorption through the Na+/glucose cotransporter (SGLT1) in the small intestine. J. Control. Release 125 (1) (2008) 42-49.
68. Shinji Sakuma, Takaomi Matsumoto, Shinji Yamashita, Yanli Wang, Zheng-Rong Lu, Conjugation of poorly absorptive drugs with mucoadhesive polymers for the improvement of oral absorption of drugs. J. Control. Release 123 (3) (2007) 195-202.
69. Shinji Sakuma, Fumie K. Tanno, Yoshie Masaoka, Makoto Kataoka, Toshio Kozaki, Ryosei Kamaguchi, Hiroyasu Kokubo, Shinji Yamashita, Effect of administration site in the gastrointestinal tract on bioavailability of poorly absorbed drugs taken after a meal. J. Control. Release 118 (1) (2007) 59-64.
70. Makoto Kataoka, Yoshie Masaoka, Shinji Sakuma, Shinji Yamashita, Effect of food intake on the oral absorption of poorly water-soluble drugs: in vitro assessment of drug dissolution and permeation assay system. J. Pharm. Sci. 95 (9) (2006) 2051-2061.
71. Yoshie Masaoka, Yusuke Tanaka, Makoto Kataoka, Shinji Sakuma, Shinji Yamashita, Site of drug absorption after oral administration: assessment of membrane permeability and luminal concentration of drugs in each segment of gastrointestinal tract. Eur. J. Pharm. Sci. 29 (3-4) (2006) 240-250.
72. 門脇祐子，中山大輔，佐久間信至，山下伸二，オメプラゾール20 mg錠の溶出試験による先発医薬品と後発医薬品の製剤学的評価，医学と薬学54 (2) (2005) 189-193．
73. Shinji Sakuma, Rika Sudo, Norio Suzuki, Hiroshi Kikuchi, Hideo Takamori, Toshiyuki Sato, Yoshiharu Minamitake, Yujiro Hayashi, Osamu Sugita, Ken-ichiro Hiwatari, Akio Kishida, Mitsuru Akashi, Human calcitonin delivered orally by means of nanoparticles composed of novel graft copolymers. J. Dispers. Sci. Technol. 24 (3-4) (2003) 623-632.
74. Shinji Sakuma, Zheng-Rong Lu, Barbara Pecharová, Pavla Kopečková, Jindřich Kopeček, N-(2-Hydroxypropyl)-methacrylamide copolymer-9-aminocamptothecin conjugate: Colon-specific drug delivery in rats. J. Bioact. Compatible Polym. 17 (5) (2002) 305-319.
75. Shinji Sakuma, Rika Sudo, Norio Suzuki, Hiroshi Kikuchi, Mitsuru Akashi Yoshimasa Ishida, Masahiro Hayashi, Behavior of mucoadhesive nanoparticles having hydrophilic polymeric chains in the intestine. J. Control. Release 81 (3) (2002) 281-290.
76. Shinji Sakuma, Norio Suzuki, Rika Sudo, Ken-ichiro Hiwatari, Akio Kishida, Mitsuru Akashi, Optimized chemical structure of nanoparticles as carriers for oral delivery of salmon calcitonin. Int. J. Pharm. 239 (1-2) (2002) 185-195.
77. Zheng-Rong Lu, Jane-Guo Shiah, Shinji Sakuma, Pavla Kopečková, Jindřich Kopeček, Design of novel bioconjugates for targeted drug delivery. J. Control. Release 78 (1-3) (2002) 165-173.
78. Shinji Sakuma, Zheng-Rong Lu, Pavla Kopečková, Jindřich Kopeček, Biorecognizable HPMA copolymer-drug conjugates for colon-specific delivery of 9-aminocamptothecin. J. Control. Release 75 (3) (2001) 365-379.
79. Shinji Sakuma, Rika Sudo, Norio Suzuki, Hiroshi Kikuchi, Mitsuru Akashi, Masahiro Hayashi, Mucoadhesion of polystyrene nanoparticles having surface hydrophilic polymeric chains in the gastrointestinal tract. Int. J. Pharm. 177 (2) (1999) 161-172.
80. Shinji Sakuma, Yoshimasa Ishida, Rika Sudo, Norio Suzuki, Hiroshi Kikuchi, Ken-ichiro Hiwatari, Akio Kishida, Mitsuru Akashi, Masahiro Hayashi, Stabilization of salmon calcitonin by polystyrene nanoparticles having surface hydrophilic polymeric chains, against enzymatic degradation. Int. J. Pharm. 159 (2) (1997) 181-189.
81. Shinji Sakuma, Norio Suzuki, Hiroshi Kikuchi, Ken-ichiro Hiwatari, Kiyotaka Arikawa, Akio Kishida, Mitsuru Akashi, Absorption enhancement of orally administered salmon calcitonin by polystyrene nanoparticles having poly(N-isopropylacrylamide) branches on their surfaces. Int. J. Pharm. 158 (1) (1997) 69-78.
82. Shinji Sakuma, Norio Suzuki, Hiroshi Kikuchi, Ken-ichiro Hiwatari, Kiyotaka Arikawa, Akio Kishida, Mitsuru Akashi, Oral peptide delivery using nanoparticles composed of novel graft copolymers having hydrophobic backbone and hydrophilic branches. Int. J. Pharm. 149 (1) (1997) 93-106.
83. 佐久間信至，大島広行，近藤保，ポリ（N, N, L-リジンジイルテレフタロイル）マイクロカプセル膜内の固定電荷分布，表面科学10 (3) (1989) 202-205．
84. Shinji Sakuma, Hiroyuki Ohshima, Tamotsu Kondo, Binding constants of metal cations to and hamaker constant for poly(N, N-L-lysinediylterephthaloyl) microcapsules. J. Colloid Interface Sci. 135 (2) (1990) 455-460.
85. Shinji Sakuma, Hiroyuki Ohshima, Tamotsu Kondo, Charge distribution in poly(N, N-L-lysinediylterephthaloyl) microcapsule membranes. J. Colloid Interface Sci. 133 (1) (1989) 253-256.

1. 八木晴也，佐久間信至，“バイオ医薬の経粘膜吸収促進を可能にする膜透過ペプチド固定化高分子の開発”「月刊「細胞」2023年8月号　中分子ペプチドが拓く明日の創薬」（2023年7月22日）pp.27-32
2. 佐久間信至，“特集によせて（FOREWORD），編集後記”「コントロールドリリースの臨床的価値と新たな方向性」，Drug Delivery System 31 (3) (2016) 183，258．
3. 佐久間信至，DDSによる創薬・創剤を目指して，薬剤学74 (6) (2014) 390-395．
4. 日渡謙一郎，佐久間信至，“オリゴアルギニン固定化高分子による低膜透過性分子の細胞膜透過促進機構とその応用”「DDS技術の進歩と医療応用（片岡一則編集）」，Medical Science Digest 40 (2) (2014) 98-102.
5. 佐久間信至，“DDS技術の実用化展開”「製剤開発の世界潮流とわが国の将来展望（橋田充編集）」，PHARM TECH JAPAN 29 (15) (2013) 3031-3037．
6. 佐久間信至，大腸内視鏡検査用造影剤「ナノビーコン」の開発，Colloid & Interface Communication 38 (4) (2013) 16-18．
7. 佐久間信至，日渡謙一郎，オリゴアルギニン固定化高分子を用いた低膜透過性分子の細胞膜透過促進，Drug Delivery System 28 (2) (2013) 109-118．
8. 佐久間信至，加藤正樹，木村敏史，藤田信明，精神疾患治療に用いられる内服薬へのControlled Release Technologyの導入とその意義，臨床精神薬理15 (8) (2012) 1387-1402．
9. 藤井義峰，佐久間信至，ナノテクノロジーは革新的な経口ドラッグデリバリーシステムの開発に貢献できるか，分子消化器病9 (2) (2012) 145-150．
10. 日渡謙一郎，佐久間信至，レクチン固定化蛍光ナノスフェアを用いた大腸がんの超早期診断法の開発，BIO Clinica 27 (3) (2012) 261-265．
11. 佐久間信至，加藤正樹，CRテクノロジーの特徴，日経メディカル，pp.118，2012年4月．
12. Shinji Sakuma, Shinji Yamashita, Ken-ichiro Hiwatari, Robert M. Hoffman, Wellington Pham, Lectin-immobilized fluorescent nanospheres for targeting to colorectal cancer from a physicochemical perspective. Curr. Drug Discov. Technol. 8 (4) (2011) 367-378.
13. 佐久間信至，ビスフォスフォネート製剤の薬物動態　～経口吸収性，食事の影響を中心に～，骨粗鬆症治療9 (4) (2010) 333-338．
14. 丹野 史枝，佐久間 信至，小久保 宏恭，山下 伸二，食後の吸収率低下の回避を目的とした新規製剤の開発：高pH溶解型腸溶性高分子の利用，Drug Delivery System 25 (4) (2010) 384-391．
15. 佐久間 信至，日渡 謙一郎，ロバート ホフマン，山下 伸二，レクチン固定化蛍光ナノスフェアを用いた大腸がんの超早期診断法の開発，Drug Delivery System 25 (4) (2010) 403-410．
16. 佐久間信至，DDS，人工臓器35 (3) (2006) 375-377．
17. 佐久間信至，DDSキャリア及び医薬品としての合成高分子の可能性，薬剤学65 (5) (2005) 284-288．
18. 山内仁史，佐久間信至，製剤技術と界面化学，Fragrance Journal 臨時増刊19 (2005) 45-51．
19. Shinji Sakuma, Masahiro Hayashi, Mitsuru Akashi, Design of nanoparticles composed of graft copolymers for oral peptide delivery. Adv. Drug Deliv. Rev. 47 (1) (2001) 21-37.
20. 佐久間信至，ナノパーティクルを用いた経口用DDSの製剤設計，Drug Delivery System 15 (5) (2000) 466-467．
21. 明石満，佐久間信至，ドラッグデリバリー用コア－コロナ型高分子微粒子，化学と教育47 (5) (1999) 309-313．

1. 佐久間信至，“注射により投与する製剤，透析に用いる製剤および目に投与する製剤”「最新製剤学第11版（尾関哲也，井上勝英編）」，廣川書店（2018年4月30日），pp.336-363．
2. Yoshimine Fujii, Shinji Sakuma, Gastrointestinal system, Chapter IV. Potential applications of nanosized materials in pharmacology, In: Zheng-Rong Lu & Shinji Sakuma (Eds.), Nanomaterials in Pharmacology, Springer Inc., New York 2016, pp.279-300.
3. 佐久間信至, "DDSにおける制御の対象技術-コントロールドリリース-, 経口投与とその改善-製剤技術による薬物吸収改善-, 経口投与とその改善-経口投与型DDS製剤-" 「図解で学ぶDDS第2版（橋田充監修, 高倉喜信編集）」, じほう（2016年9月20日）, pp. 37-44, 69-76, 77-86.
4. Yoshimine Fujii, Shinji Sakuma, Gastrointestinal system, Chapter IV. Potential applications of nanosized materials in pharmacology, In: Zheng-Rong Lu & Shinji Sakuma (Eds.), Nanomaterials in Pharmacology, Springer Inc., New York2016, pp.279-300.
5. 佐久間信至，“Ⅳ. 16. 3. 5 ドラッグデリバリーシステム製剤技術”「化学便覧 応用化学編 第7版（公益社団法人 日本化学会 編）」，丸善出版（2014年1月30日），pp. 1037-1040．
6. 佐久間信至，“注射により投与する製剤，透析に用いる製剤，製剤に用いる添加剤”「図解製剤学第1版（杉林堅次編）」，南山堂（2013年4月1日），pp.84-97，98-99，138-145．
7. 丹野史枝，佐久間信至，“高pH溶解型腸溶性高分子を用いた小腸中部～下部への薬物デリバリー技術の開発”「難吸収性薬物の吸収性改善と新規投与製剤の開発（山本昌監修）」，シーエムシー出版（2012年4月2日），pp.141-148．
8. 佐久間信至，“注射により投与する製剤，透析に用いる製剤および目に投与する製剤”「最新製剤学第10版（林正弘，尾関哲也，乾賢一編）」，廣川書店（2012年4月1日），pp.303-330．
9. 佐久間信至，菊池寛，林正弘，明石満，“粘膜付着性ナノパーティクルを用いたカルシトニンの消化管吸収性の改善”「ペプチド・タンパク性医薬品の新規DDS製剤の開発と応用（山本昌編集）」，メディカルドゥ（2011年6月10日），pp.134-140．
10. 佐久間信至，“DDSの目的と技術－コントロールドリリース－，経口投与とその改善－製剤技術による薬物吸収改善－，経口投与とその改善－経口投与型DDS製剤－”「図解で学ぶDDS（橋田充監修，高倉喜信編集）」，じほう（2010年8月15日），pp.34-40，64-71，72-78．
11. 佐久間信至，“溶解度と溶解速度”「難水溶性薬物の物性評価と製剤設計の新展開（川上亘作監修）」，シーエムシー出版（2010年1月29日），pp.84-91．
12. 佐久間信至，“マイクロスフェア・ナノスフェア”「第3版　現代界面コロイド化学の基礎（小山昇，岩橋槇夫，川上亘作，芳賀正明，田村隆光，三輪哲也編）」，丸善（2009年4月25日），pp.163-165．
13. 佐久間信至，“無菌製剤”「最新製剤学第9版（林正弘，川島嘉明，乾賢一編）」，廣川書店（2006年9月25日），pp.313-338．
14. 山内仁史，佐久間信至　訳，“薬剤学における界面化学” 「応用界面・コロイド化学ハンドブック（辻井薫監修）」，エヌ・ティー・エス（2006年1月31日），pp.3-38．
15. 山内仁史，佐久間信至，“医療・食品における殺菌・消毒及び静菌，医療用界面活性剤”「最新・界面活性剤の機能創製・素材開発・応用技術（堀内照夫，鈴木敏幸編）」，技術教育出版社（2005年10月25日），pp.204-210, 253-266．
16. 佐久間信至，山内仁史，高杉紀雄，“微粒子製剤”「経口投与製剤の設計と評価（橋田充編）」，薬業時報社（1995年2月10日），pp.232-250.

ページトップへ